Guanylyl cyclase structure, function and regulation.
Guanylyl cyclase structure, function and regulation.
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DOI：
10.1016/j.cellsig.2011.09.001
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发表时间：
2011-12
影响因子：
4.8
通讯作者：
Potter LR
中科院分区：
文献类型：
--
作者：
Potter LR
一氧化氮、碳酸氢盐、利钠肽（ANP、BNP和CNP）、鸟苷酸、尿鸟苷酸和鸟苷酸环化酶激活蛋白（GCAP）激活不同地称为鸟苷酸、鸟苷酸或鸟苷酸环化酶的酶家族，所述酶家族催化三磷酸鸟苷转化为环磷酸鸟苷（cGMP）和焦磷酸。细胞内环GMP是第二信使，其调节：血小板聚集、神经传递、性唤起、肠道蠕动、血压、长骨生长、肠液分泌、脂解、光转导、心脏肥大和卵母细胞成熟。本文简要介绍了环鸟苷酸和鸟苷酸环化酶的发现，然后对一氧化氮、一氧化氮合酶和可溶性鸟苷酸环化酶作了较为详细的介绍。最后，结构，功能和调节的个别哺乳动物单跨膜鸟苷酸环化酶GC-A，GC-B，GC-C，GC-D，GC-E，GC-F和GC-G的描述最详细的生化，细胞生物学和基因缺失的研究确定。
Nitric oxide, bicarbonate, natriuretic peptides (ANP, BNP and CNP), guanylins, uroguanylins and guanylyl cyclase activating proteins (GCAPs) activate a family of enzymes variously called guanyl, guanylyl or guanylate cyclases that catalyze the conversion of guanosine triphosphate to cyclic guanosine monophosphate (cGMP) and pyrophosphate. Intracellular cyclic GMP is a second messenger that modulates: platelet aggregation, neurotransmission, sexual arousal, gut peristalsis, blood pressure, long bone growth, intestinal fluid secretion, lipolysis, phototransduction, cardiac hypertrophy and oocyte maturation. This review briefly discusses the discovery of cGMP and guanylyl cyclases, then nitric oxide, nitric oxide synthase and soluble guanylyl cyclase are described in slightly greater detail. Finally, the structure, function, and regulation of the individual mammalian single membrane-spanning guanylyl cyclases GC-A, GC-B, GC-C, GC-D, GC-E, GC-F and GC-G are described in greatest detail as determined by biochemical, cell biological and gene-deletion studies.