Antioxidant enzyme expression and reactive oxygen species damage in prostatic intraepithelial neoplasia and cancer
Antioxidant enzyme expression and reactive oxygen species damage in prostatic intraepithelial neoplasia and cancer
复制标题
DOI：
10.1002/1097-0142(20000701)89:1
复制
发表时间：
2000-07
期刊：
影响因子：
6.2
通讯作者：
D. Bostwick;Erik E. Alexander;Rohini Singh;A. Shan;J. Qian;R. Santella;L. Oberley;T. Yan;W. Zhong;Xiaohong Jiang;T. Oberley
中科院分区：
文献类型：
--
作者：
D. Bostwick;Erik E. Alexander;Rohini Singh;A. Shan;J. Qian;R. Santella;L. Oberley;T. Yan;W. Zhong;Xiaohong Jiang;T. Oberley
Oxidative stress results in damage to cellular structures and has been linked to many diseases, including cancer. The authors sought to determine whether the expression of three major antioxidant enzymes, copper‐zinc superoxide dismutase (SOD1), manganese superoxide dismutase (SOD2), and catalase, was altered in human prostate carcinoma and its likely precursor, high grade prostatic intraepithelial neoplasia (PIN). The level of reactive oxygen species damage was evaluated by measuring the expression of the DNA adduct 8‐hydroxydeoxyguanosine.
