Transporter oligomerization: form and function.
Transporter oligomerization: form and function.
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DOI：
10.1042/bst20160217
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发表时间：
2016-12-15
影响因子：
3.9
通讯作者：
Byrne B
中科院分区：
文献类型：
--
作者：
Alguel Y;Cameron AD;Diallinas G;Byrne B
转运蛋白是一种完整的膜蛋白，在分子在生物膜上的有效移动中起着核心作用。许多转运蛋白以寡聚体的形式存在于细胞膜中。根据不同的转运蛋白，寡聚可以在膜的运输、功能、调节和周转中发挥作用。例如，我们最近对来自nidulans的核酸基抗坏血酸转运体UapA的研究揭示了这种蛋白质的二聚化对于正确地转运到膜上是必不可少的，也揭示了一个UapA原基如何影响密切相关的相邻原基的功能的结构基础。在这里，我们回顾了寡聚在许多特别研究得很好的转运蛋白和转运蛋白家族中的作用。
Transporters are integral membrane proteins with central roles in the efficient movement of molecules across biological membranes. Many transporters exist as oligomers in the membrane. Depending on the individual transport protein, oligomerization can have roles in membrane trafficking, function, regulation and turnover. For example, our recent studies on UapA, a nucleobase ascorbate transporter, from Aspergillus nidulans, have revealed both that dimerization of this protein is essential for correct trafficking to the membrane and the structural basis of how one UapA protomer can affect the function of the closely associated adjacent protomer. Here, we review the roles of oligomerization in many particularly well-studied transporters and transporter families.