When and why are mitochondria paternally inherited?
When and why are mitochondria paternally inherited?
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DOI：
10.1016/j.gde.2023.102053
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发表时间：
2023-05
影响因子：
4
通讯作者：
Manisha Munasinghe;J. Ågren
中科院分区：
文献类型：
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作者：
Manisha Munasinghe;J. Ågren
亮点线粒体基因组的单亲遗传有助于减轻基因组内冲突，并允许针对自私突变进行选择。线粒体基因组的排他性父系遗传很少见，仅在某些植物物种中发现。父系遗传的进化知之甚少，但可能受到基因组大小和不稳定性的影响。葫芦科为探索父系遗传的进化提供了有利的系统。与核遗传相比，线粒体基因是通过父母双方传递的，在大多数物种中，大多数时候，线粒体基因是母系遗传的。这种传递不对称性所导致的遗传冲突是有据可查的，与此相关的群体遗传学理论也很多。虽然偶尔或异常的父系遗传会发生，但只有少数情况下线粒体基因组的排他性父系遗传是进化状态。为什么这一点仍然知之甚少。通过研究物种之间的共同点，独家父系遗传，我们讨论了他们可能会告诉我们的进化力量影响线粒体遗传模式。最后，我们讨论了最近的技术进步，使探索父系遗传的原因和后果可行。
HighlightsUniparental inheritance of mitochondrial genomes helps mitigate intragenomic conflict and allows for selection against selfish mutations.Exclusive paternal inheritance of mitochondrial genomes is rare and found only in certain plant species.The evolution of paternal inheritance is poorly understood but may be influenced by genome size and instability.The Cucurbitaceae family offers a favorable system to explore the evolution of paternal inheritance.In contrast with nuclear genes that are passed on through both parents, mitochondrial genes are maternally inherited in most species, most of the time. The genetic conflict stemming from this transmission asymmetry is well-documented, and there is an abundance of population-genetic theory associated with it. While occasional or aberrant paternal inheritance occurs, there are only a few cases where exclusive paternal inheritance of mitochondrial genomes is the evolved state. Why this is remains poorly understood. By examining commonalities between species with exclusive paternal inheritance, we discuss what they may tell us about the evolutionary forces influencing mitochondrial inheritance patterns. We end by discussing recent technological advances that make exploring the causes and consequences of paternal inheritance feasible.