Natural β-Dihydroagarofuran-Type Sesquiterpenoids as Cognition-Enhancing and Neuroprotective Agents from Medicinal Plants of the Genus Celastrus
Natural β-Dihydroagarofuran-Type Sesquiterpenoids as Cognition-Enhancing and Neuroprotective Agents from Medicinal Plants of the Genus Celastrus
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天然 β-二氢沉香呋喃型倍半萜类化合物作为来自南藤属药用植物的认知增强剂和神经保护剂。
DOI：
10.1021/acs.jnatprod.5b00234
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发表时间：
2015-09-01
影响因子：
5.1
通讯作者：
Zhao, Weimin
中科院分区：
文献类型：
--
作者：
Ning, Ruonan;Lei, Yun;Zhao, Weimin
Alzheimer's disease (AD) is an irreversible, multifaceted, and progressive neurodegenerative disorder. Over the past 30 years, the search for anti-AD drugs has been primarily based on the cholinergic deficiency hypothesis and/or the beta-amyloid (A beta) cascade hypothesis. In this study, we report the identification of 16 new and 38 known beta-dihydroagarofuran-type sesquiterpenoids from Celastrus flagellaris and Celastrus angulatus. The beta-dihydroagarofuran-type sesquiterpenoids 58, 59, 61, and 63 significantly attenuated scopolamine-induced prolonged escape latency and increased number of errors compared with the control group. At 10 mu M, 21 of the 62 tested beta-dihydroagarofuran-type sesquiterpenoids rescued A beta(25-35)-induced SH-SY5Y cells from viability reduction, which increased the cell viability from 64.6% for the model to more than 74.0%. The majority of the beta-dihydroagarofuran-type sesquiterpenoids with ester groups exhibited stronger activity than those with free hydroxy groups or without substituents at the same positions. These results identified a new chemical skeleton as drug lead for the investigation of novel therapeutic agents against AD.
