Augmentation of thyrotropin responses to thyrotropin-releasing hormone following small decreases in serum thyroid hormone concentrations.
Augmentation of thyrotropin responses to thyrotropin-releasing hormone following small decreases in serum thyroid hormone concentrations.
复制标题
血清甲状腺激素浓度小幅降低后，促甲状腺激素对促甲状腺激素释放激素的反应增强。
DOI：
--
复制
发表时间：
1975
影响因子：
5.8
通讯作者：
R. Utiger
中科院分区：
文献类型：
--
作者：
M. Saberi;R. Utiger
为了确定血清甲状腺激素浓度的轻微下降是否会导致促甲状腺激素（TSH）对促甲状腺激素释放激素（TRH）的反应增强，在20名正常受试者接受碘化物治疗13天前后测定了TSH对TRH的反应。正常受试者每日接受50或250 mg碘化物治疗后，血清甲状腺素（t4）和/或三碘甲状腺原氨酸（T3）浓度轻微降低，基础血清TSH浓度轻微升高，但血清T4、T3和TSH浓度仍在各自的正常范围内。相反，TSH对TRH的反应在碘化物治疗期结束时显著更大。在每天接受50 mg碘化物的受试者中，平均基础血清TSH浓度在碘化物之前为3.1和3.2 μ U/ml，在碘化物之后为4.9和4.6 μ U/ml。促甲状腺激素释放激素治疗后血清TSH平均峰值浓度碘化前为14.2 μ U/ml，碘化后为27.4 μ U/ml（P <0.01）。在每天接受250 mg碘化物的受试者中发现了非常相似的血清TSH峰值增加（碘化物前，峰值TSH为17.2 μ U/ml;碘化物后，峰值TSH为28.7 μ U/ml）。4例甲状腺功能减退症患者服用碘剂后，血清T4、T3或TSH浓度或TSH对TRH的反应均无变化。这些结果表明，血清T4和T3浓度的轻微降低导致垂体对TRH的敏感性增加，正如血清T4和T3浓度的轻微增加降低对TRH的敏感性一样。
To determine whether slight decreases in serum thyroid hormone concentrations resulted in augmentation of the thyrotropin (TSH) response to thyrotropin-releasing hormone (TRH), TSH responses to TRH were determined before and after 13 days of iodide treatment in 20 normal subjects. Slight reductions in serum thyroxine (t4) and/or triiodothyronine (T3) concentrations and slight increases in basal serum TSH concentrations occurred in normal subjects treated with 50 or 250 mg iodide daily, though serum T4, T3 and TSH concentrations remained within their respective normal range. In contrast, TSH responses to TRH were significantly greater at the end of the iodide treatment period. In the subjects who received 50 mg iodide daily, mean basal serum TSH concentrations were 3.1 and 3.2 muU/ml before and 4.9 and 4.6 muU/ml after iodide. Post-TRH mean peak serum TSH concentrations were 14.2 muU/ml before and 27.4 muU/ml after iodide (P smaller than 0.01). A very similar augmentation of peak serum TSH was found in the subjects who received 250 mg iodide daily (before iodide, peak TSH 17.2 muU/ml; after iodide, peak TSH 28.7 muU/ml). No changes in serum T4, T3 or TSH concentrations or TSH responses to TRH followed iodide administration in 4 thyroxine-treated hypothyroid patients. These results indicate that slight reductions in serum T4 AND T3 concentrations result in increased pituitary sensitivity to TRH, just as small increases in serum T4 and T3 concentrations decrease sensitivity to TRH.