Bacterial Therapy of Cancer: Promises, Limitations, and Insights for Future Directions.
Bacterial Therapy of Cancer: Promises, Limitations, and Insights for Future Directions.
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DOI：
10.3389/fmicb.2018.00016
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发表时间：
2018
影响因子：
5.2
通讯作者：
Hoffman RM
中科院分区：
文献类型：
--
作者：
Kramer MG;Masner M;Ferreira FA;Hoffman RM
自发性肿瘤消退与微生物感染有关已有100多年的历史，并启发了细菌用于抗癌治疗。威廉B博士。骨肉瘤外科医生Coley（1862-1936）是用活细菌和热灭活细菌混合物（称为“Coley毒素”）治疗患者的先驱。不幸的是，科利被迫停止他的工作中断了这一领域约半个世纪。目前，正在开发几种细菌来对抗癌症。细菌种类、它们的遗传背景和它们在肿瘤微环境中的感染行为被认为是决定它们在体内抗肿瘤有效性的相关因素。在这篇前瞻性文章中，我们将更新在临床相关的癌症动物模型中使用细菌治疗（单独或与其他策略相结合）取得的最有希望的结果，并严格讨论细菌变体的影响，给药途径和细菌-癌细胞相互作用的机制。我们还将讨论利用现代小鼠模型、分子生物学、遗传学和成像技术将这些信息应用于未来癌症患者细菌治疗的策略。
Spontaneous tumors regression has been associated with microbial infection for 100s of years and inspired the use of bacteria for anticancer therapy. Dr. William B. Coley (1862–1936), a bone- sarcoma surgeon, was a pioneer in treating his patients with both live bacterial-based and mixture of heat-killed bacteria known as “Coley’s toxins.” Unfortunately, Coley was forced to stop his work which interrupted this field for about half a century. Currently, several species of bacteria are being developed against cancer. The bacterial species, their genetic background and their infectious behavior within the tumor microenvironment are thought to be relevant factors in determining their anti-tumor effectiveness in vivo. In this perspective article we will update the most promising results achieved using bacterial therapy (alone or combined with other strategies) in clinically-relevant animal models of cancer and critically discuss the impact of the bacterial variants, route of administration and mechanisms of bacteria-cancer-cell interaction. We will also discuss strategies to apply this information using modern mouse models, molecular biology, genetics and imaging for future bacterial therapy of cancer patients.
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影响因子：
10.1
作者：
Binder DC;Engels B;Arina A;Yu P;Slauch JM;Fu YX;Karrison T;Burnette B;Idel C;Zhao M;Hoffman RM;Munn DH;Rowley DA;Schreiber H
通讯作者：
Schreiber H
影响因子：
--
作者：
Hiroshima Y;Maawy A;Zhang Y;Zhang N;Murakami T;Chishima T;Tanaka K;Ichikawa Y;Bouvet M;Endo I;Hoffman RM
通讯作者：
Hoffman RM
影响因子：
3.8
作者：
Cho SY;Kang W;Han JY;Min S;Kang J;Lee A;Kwon JY;Lee C;Park H
通讯作者：
Park H
影响因子：
5.7
作者：
Alonso A;Marsal S;Julià A
通讯作者：
Julià A
影响因子：
3.1
作者：
Elahian, Fatemeh;Moghimi, Bahareh;Mirzaei, Seyed Abbas
通讯作者：
Mirzaei, Seyed Abbas