Is sprouting the result of a persistent neonatal connection?
Is sprouting the result of a persistent neonatal connection?
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发芽是新生儿持久联系的结果吗？
DOI：
10.1016/0304-3940(80)90252-9
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发表时间：
1980
影响因子：
2.5
通讯作者：
S. Leong
中科院分区：
文献类型：
--
作者：
S. H. Nah;Lean Swee Ong;S. Leong
本研究旨在验证这一假设，即早期新生儿的联系可能解释了中枢神经系统中的某些萌发现象。用Fink-Hemer‘s轴突退化法、电子显微镜和放射自显影技术追踪新生大鼠运动感觉皮质(SMC)的皮质分离投射。结果显示，新生儿皮质醇向上丘、红核和脊髓的投射是单侧的，不能解释新生儿SMC病变后即刻双侧皮质醇向这些区域的投射[8，10，12，13]。新生儿对侧桥脑皮质投影的存在也不足以解释新生儿单侧SMC损伤后对侧桥脑投影的存在，但可能解释新生儿单侧小脑半球切除术后对侧桥脑投影的存在[11]。
The present study aims to test the hypothesis that early neonatal connections might account for certain sprouting phenomena in the central nervous system. Fink-Heimer's method for degenerating axons, electron microscopy and autoradiography were used to trace the neonatal corticofugal projections from the sensorimotor cortex (SMC) of albino rats. The results showed that neonatal corticofugal projections to the superior colliculus, red nucleus and spinal cord were unilateral and could not explain the bilateral corticofugal projections to these areas soon after neonatal SMC lesions [8, 10, 12, 13]. The presence of a neonatal contralateral corticopontine projection is also not sufficient to account for the presence of a contralateral corticopontine projection seen after neonatal unilateral SMC lesion, but might account for the contralateral corticopontine projection seen after neonatal unilateral cerebellar hemispherectomy [11].