Helix formation in synthetic polymers by hydrogen bonding with native saccharides in protic media.
Helix formation in synthetic polymers by hydrogen bonding with native saccharides in protic media.
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DOI：
10.1002/chem.200600315
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发表时间：
2006-10
期刊：
影响因子：
--
通讯作者：
M. Waki;H. Abe;M. Inouye
中科院分区：
文献类型：
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作者：
M. Waki;H. Abe;M. Inouye
设计了水溶性聚间乙炔基吡啶，实现了在质子介质中对糖的识别。UV/维斯、1H NMR和荧光光谱研究表明，聚合物在质子介质中通过乙炔基吡啶单元之间的疏溶剂相互作用形成了螺旋状的高阶结构.螺旋结构中的孔就像蛋白质中的结合口袋，利用了聚合物中向内的氢键官能团。用圆二色性（CD）研究了聚合物对天然染料的分子识别。糖的手性被转移到聚合物的螺旋意义上，伴随着诱导CD（ICD）的出现在聚合物的吸收区域。在甲醇/水（10/1）溶液中，甘露糖和阿洛糖表现出强烈的ICDs，聚合物与D-甘露糖的表观缔合常数为14 M（-1）。
Water-soluble poly(m-ethynylpyridine)s were designed to realize saccharide recognition in protic media. UV/Vis, 1H NMR, and fluorescence measurements revealed that the polymer forms a helical higher order structure by solvophobic interactions between the ethynylpyridine units in the protic medium. The resulting pore in the helix behaves like a binding pocket in proteins, by taking advantage of inwardly directed hydrogen-bonding functional groups of the polymers. Molecular recognition of native saccharides by the polymers was investigated by circular dichroism (CD). The chirality of the saccharide was transferred to the helical sense of the polymers, accompanied by the appearance of induced CDs (ICDs) in the absorptive region of the polymers. In MeOH/water (10/1), mannose and allose showed intense ICDs, and the apparent association constant between the polymer and D-mannose was 14 M(-1).