Production of antigen-nonspecific immunoregulatory lymphokines by T cell hybridomas.
Production of antigen-nonspecific immunoregulatory lymphokines by T cell hybridomas.
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T 细胞杂交瘤生产抗原非特异性免疫调节淋巴因子。
DOI：
10.1007/978-3-642-68586-6_21
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发表时间：
1982
影响因子：
--
通讯作者：
Katz,DH
中科院分区：
文献类型：
--
作者：
Altman,A;Schreiber,RD;Katz,DH
在过去的12年中，大量具有免疫调节和其他生物活性的非免疫球蛋白可溶性介质或淋巴因子（LK）被研究。这些LK大多数是抗原或多克隆有丝分裂原激活的T细胞的产物。T细胞衍生LK的研究受到传统培养中LK数量有限和产生LK的细胞群体异质性的严重阻碍，这反过来导致许多不同LK的异质混合物。由于这些限制，很难描述LK的确切化学性质，各种生物活性之间的结构-功能关系及其生物学意义。
A large number of non-immunoglobulin soluble mediators or lymphokines (LK) with immunoregulatory and other biological activities have been studied over the last 12 years. The majority of these LK are products of T cells activated by antigens or polyclonal mitogens. Studies on T cell-derived LK have been severely hampered by the limited amounts of LK available from conventional cultures and the heterogeneity of the cell populations producing these LK which, in turn, resulted in heterogeneous mixtures of many distinct LK. As a result of these limitations, it has been difficult to delineate the exact chemical nature of LK, the structure-function relationship among various biological activities and their biological significance.