Collateralization of monoamine neurons: mesotelencephalic dopamine projections to caudate, septum, and frontal cortex
Collateralization of monoamine neurons: mesotelencephalic dopamine projections to caudate, septum, and frontal cortex
复制标题
单胺神经元的侧支：中脑多巴胺投射到尾状核、隔膜和额叶皮层
作者：
J. Fallon
采用荧光染料多重逆行标记技术对大鼠黑质（SN）和腹侧被盖区（VTA）神经元轴突侧支进行了研究。在尾状壳核、隔膜和额叶皮层注射核黄、颗粒蓝和碘化丙啶，在SN-VTA上发现细胞为单、双、三重标记。三种示踪剂对VTA内的细胞以单标记为主，对内侧SN内的细胞以双标记为主。这些结果表明，根据侧枝的相对程度，SN-VTA的中端脑神经元可以细分为两个亚群。SN轴突似乎与解剖学和功能上不同的远端脑区高度侧支，VTA轴突似乎与相同的前脑区有更单一的一对一投射。
Axonal collateralization of substantia nigra (SN) and ventral tegmental area (VTA) neurons was studied in the rat with the multiple retrograde labeling technique using fluorescent dyes. Injections of nuclear yellow, granular blue, and propidium iodide were made into the caudate- putamen, septum, and frontal cortex and cells were found to be single, double, and triple labeled in the SN-VTA. Cells in the VTA were predominantly single labeled with the three tracers and cells in the medial SN were predominantly double labeled with the tracers. These results suggest that mesotelencephalic neurons in the SN-VTA can be subdivided into two subpopulations on the basis of relative degree of collateralization. The SN axons appear to be highly collateralized to anatomically and functionally distinct telencephalic areas and the VTA axons appear to have a more singular one-to-one type of projection to the same forebrain regions.