Gait profiles as indicators of domain-specific impairments in executive control across neurodevelopmental disorders
Gait profiles as indicators of domain-specific impairments in executive control across neurodevelopmental disorders
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DOI：
10.1016/j.ridd.2013.10.005
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发表时间：
2014-01-01
影响因子：
3.1
通讯作者：
Porter, Melanie A.
中科院分区：
文献类型：
--
作者：
Hocking, Darren R.;Menant, Jasmine C.;Porter, Melanie A.
在神经发育障碍中，执行控制和注意力的独特特征似乎与运动协调性差同时发生。然而，很少有人知道的综合征特异性认知配置文件如何与运动控制和影响行为结果的神经发育障碍，如威廉姆斯综合征（WS）和唐氏综合征（DS）。在这里，我们的目的是研究在何种程度上执行功能的特定组件与步态控制时，执行认知的双重任务（言语流畅性，数字跨度）在WS和DS。时空步态特征和步态的个体内变异性进行了评估，在个人与WS谁是匹配的空间能力，个人与DS，和时间年龄（CA）匹配的控制。在同时进行的语言流畅性任务中，WS组在时空步态参数和变异性方面的双重任务成本高于CA对照组。相反，个人与DS有选择性步态干扰在并发的数字跨度任务相比，CA控制，但只有在认知控制的需求增加，有更大的变化，在DS的步骤时间。认知运动的干扰和行为的执行功能的措施之间的相互关系出现WS和DS之间的区别，并强调任务方式在解开这些神经发育障碍的执行控制配置文件的重要性。这些研究结果支持的概念，相关的小脑皮质异常可能会产生相当不同的配置文件的执行控制跨认知和运动领域的行为结果的影响，在神经发育障碍。(C)2013爱思唯尔有限公司保留所有权利。
In neurodevelopmental disorders, unique profiles of executive control and attention appear to co-occur with poor motor coordination. However, less is known about how syndrome-specific cognitive profiles interact with motor control and impact behavioural outcomes in neurodevelopmental disorders such as Williams syndrome (WS) and Down syndrome (DS). Here we aimed to examine the extent to which specific components of executive function interact with gait control when performing cognitive dual-tasks (verbal fluency, digit span) in WS and DS. Spatiotemporal gait characteristics and intra-individual variability of gait were assessed in individuals with WS who were matched on spatial ability to individuals with DS, and chronologically age (CA) matched controls. During the concurrent verbal fluency task, the WS group had greater dual-task costs on spatiotemporal gait parameters and variability than CA controls. Conversely, individuals with DS had selective gait interference during the concurrent digit span task when compared to CA controls, but only under increased demands on cognitive control where there was greater variability in step timing in DS. The interrelationships between cognitive-motor interference and behavioural measures of executive functioning appeared to differentiate between WS and DS, and emphasise the importance of task modality in unpacking the executive control profile in these neurodevelopmental disorders. These findings support the notion that associated cerebellar-cortico abnormalities may produce quite distinct profiles of executive control across cognitive and motor domains that impact on behavioural outcomes in neurodevelopmental disorders. (C) 2013 Elsevier Ltd. All rights reserved.