3' untranslated region 1630 C>T polymorphism of prohibitin increases risk of breast cancer.
3' untranslated region 1630 C>T polymorphism of prohibitin increases risk of breast cancer.
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DOI：
10.2147/ott.s40997
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发表时间：
2013
影响因子：
4
通讯作者：
Guan X
中科院分区：
文献类型：
--
作者：
Tang L;Zhao Y;Nie W;Wang Z;Guan X
Prohibitin 3′非翻译区1630 C>T（rs6917）多态性产生了一个变体T等位基因，该等位基因缺乏更常见的功能性C等位基因的抗增殖活性。先前的研究表明，携带抑制素T等位基因的女性患乳腺癌的易感性增加。然而，1630 C>T多态性在抑制素mRNA表达中的作用及其在乳腺癌发生中的作用仍存在争议。利用HapMap在线数据库中的mRNA表达数据，我们寻找了prohibitin 1630 C>T多态性与其mRNA表达之间的关联，然后进行了prohibitin 1630 C>T多态性与乳腺癌风险的荟萃分析。虽然在HapMap数据库中未发现prohibitin 1630 C>T多态性与淋巴母细胞样细胞系mRNA表达之间存在显著相关性，（P趋势= 0.543），本荟萃分析包括5072例病例和4796例对照，在等位基因对比模型T vs. C中，Prohibitin 1630 C>T多态性与乳腺癌风险显著相关（比值比[OR] 1.09，95%可信区间[CI] 1.01-1.18），纯合子共显性模型TT与CC（OR 1.47，95%CI 1.12-1.92），隐性模型TT与CC/CT（OR 1.45，95%CI 1.10-1.89）。我们的研究表明，Prohibitin 1630 C>T多态性的次要等位基因T与乳腺癌易感性增加有关。
Prohibitin 3′ untranslated region 1630 C>T (rs6917) polymorphism creates a variant T allele that lacks the antiproliferative activity of the more common functional C allele. Previous studies indicate that women carrying the prohibitin T allele have an increased susceptibility to breast cancer. However, the role of 1630 C>T polymorphism in mRNA expression of prohibitin and its contribution to carcinogenesis in the breast remains controversial. Using mRNA expression data from the HapMap online database, we sought an association between prohibitin 1630 C>T polymorphism and its mRNA expression, then conducted a meta-analysis of prohibitin 1630 C>T polymorphism and risk of breast cancer. Although no significant association was found between prohibitin 1630 C>T polymorphism and mRNA expression in lymphoblastoid cell lines from the HapMap database (Ptrend = 0.543), the present meta-analysis involving 5072 cases and 4796 controls demonstrated that prohibitin 1630 C>T polymorphism was significantly correlated with breast cancer risk in allele contrast model T versus C (odds ratio [OR] 1.09, 95% confidence interval [CI] 1.01–1.18), the homozygote codominant model TT versus CC (OR 1.47, 95% CI 1.12–1.92), and the recessive model TT versus CC/CT (OR 1.45, 95% CI 1.10–1.89). Our study indicates that minor allele T of prohibitin 1630 C>T polymorphism is associated with increased susceptibility to breast cancer.