Recent Advances on Fluorescence Imaging of Lymphatic Vasculature System
Recent Advances on Fluorescence Imaging of Lymphatic Vasculature System
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淋巴脉管系统荧光成像的最新进展
DOI：
10.21127/yaoyigc20190015
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发表时间：
2019-12
期刊：
影响因子：
--
通讯作者：
Liqin Xiong
中科院分区：
文献类型：
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作者：
Yi Li;Liqin Xiong
淋巴管系统因其在水肿、免疫功能障碍、肠道吸收不良和淋巴结转移等病理变化中的重要作用而受到广泛关注，随着荧光成像技术的不断发展，其在临床前和临床上已广泛应用于淋巴管结构、形态和功能的研究。荧光成像可以帮助研究者和临床医生了解淋巴管的形态和功能状态，探讨淋巴管在各种淋巴相关疾病中的作用，并帮助诊断患者的淋巴管状态和制定进一步的治疗方案。本文主要介绍了免疫荧光成像、光学相干断层成像、近红外荧光成像等荧光成像技术在离体和体内淋巴管造影中的应用和最新进展，并对荧光成像技术在淋巴管造影中的应用前景进行了展望。
Lymphatic vasculature system has attracted extensive attention due to its important role in some pathological changes such as lymphedema, immune dysfunction, gut malabsorption and lymph node metastasis, etc. With the continuous development of fluorescence imaging technology, it has been widely used in the study of lymphatic vessels structure, morphology, and function both in preclinical and clinical. Fluorescence imaging can help researchers and clinicians to know the morphological and functional status of lymphatic vessels, explore the role of lymphatic vessels in various lymph-related diseases, and help diagnosis the state of lymphatic vessels in patients and formulate further treatment plan. Herein, we describe the usage and recent advances of fluorescence imaging technology including immune fluorescence imaging, optical coherence tomography, near-infrared fluorescence imaging in ex vivo and in vivo lymphangiography, and discuss the future applications of fluorescence imaging in lymphatic vasculature imaging.