Diabetes as a risk factor for herpes zoster infection: Results of a population-based study in Israel
Diabetes as a risk factor for herpes zoster infection: Results of a population-based study in Israel
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DOI：
10.1007/s15010-007-6347-x
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发表时间：
2008-06-01
期刊：
影响因子：
7.5
通讯作者：
Shalev, V.
中科院分区：
文献类型：
--
作者：
Heymann, A. D.;Chodick, G.;Shalev, V.
背景资料：研究表明，糖尿病（DM）往往伴随着受损的细胞介导的免疫，这可能会增加感染性疾病，包括带状疱疹（HZ）的风险。然而，关于DM和HZ之间关系的数据很少。本病例对照研究探讨了DM和HZ.Patients和方法之间的关联：本研究嵌套在一个队列的所有成员的一个大型健康维护组织（HMO）在以色列。2002年至2006年期间，共有22,294名成员被诊断为HZ。对照组（n = 88，895）从其余HMO人群中随机选择，使用频率匹配的年龄，性别和随访时间。糖尿病，淋巴瘤，白血病，或艾滋病的历史上的个人资料，从计算机化的医疗records.Results：调整后的分析表明，HZ的风险与历史的白血病，淋巴瘤，使用类固醇或抗肿瘤药物，艾滋病，特别是在45岁以下的患者。多因素分析显示，糖尿病患者发生HZ的危险性增加（OR = 1.53，95%CI：1.44-1.62）。结论：糖尿病患者发生HZ的危险性增加。精心设计的队列研究可能有助于澄清这种关联的性质。
Background: Studies showed that diabetes mellitus (DM) is often accompanied by impaired cell-mediated immunity, which potentially may increase the risk for infectious diseases, including herpes zoster (HZ). However, data on the relation between DM and HZ are scarce. This case-control study explored the association between DM and HZ.Patients and Methods: This study was nested within a cohort of all members of a large health maintenance organization (HMO) in Israel. Cases totaled 22,294 members who were diagnosed with HZ between 2002 and 2006. Controls (n = 88,895) were randomly selected from the remaining HMO population using frequency-matched age, sex, and duration of follow-up. Personal data on history of DM, lymphoma, leukemia, or AIDS, were obtained from computerized medical records.Results: Adjusted analyses showed that the risk of HZ was associated with history of Leukemia, lymphoma, use of steroids or antineoplastic medications, and AIDS, particularly among patients below 45 years of age. In a multivariate analysis, DM was associated with an increased risk of HZ (OR = 1.53; 95% CI: 1.44-1.62).Conclusions: The data suggest that individuals with DM are at increased risk of HZ. Well-designed cohort studies may help to clarify the nature of this association.