Interaction of alcohol and tobacco in laryngeal cancer.
Interaction of alcohol and tobacco in laryngeal cancer.
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酒精和烟草在喉癌中的相互作用。
DOI：
10.1093/oxfordjournals.aje.a113315
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发表时间：
1982
影响因子：
5
通讯作者：
Rothman,KJ
中科院分区：
文献类型：
--
作者：
Flanders,WD;Rothman,KJ
饮酒和吸烟都是公认的喉癌的危险因素。作者使用先前研究的病例对照数据来估计先前提出的这两种危险因素之间相互作用指数的价值。除了先前提出的用于估计汇总指数的暴露类别加权程序外，他们还应用了最大似然技术来促进估计。总的来说，他们发现酒精和烟草在增加喉癌风险方面有适度的协同作用，因为暴露于这两种因素的风险增加了大约50%，而如果烟草和酒精的影响只是简单的相加的话。
Both alcohol and tobacco use are accepted risk factors for laryngeal cancer. The authors used case-control data from previous studies to estimate the value of a previously proposed index of interaction between these two risk factors. in addition to the weighting procedure over exposure categories that was previously proposed for estimating a summary index, they applied maximum-likelihood techniques to facilitate the estimation. Overall, they found moderate synergy between alcohol and tobacco in increasing the risk of laryngeal cancer, in that exposure to both factors increased the risk about 50% more than the increase predicted if the effects of tobacco and alcohol were simply additive.