Oxidation of low density lipoproteins in the pathogenesis of atherosclerosis
Oxidation of low density lipoproteins in the pathogenesis of atherosclerosis
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DOI：
10.1016/s0021-9150(97)00305-5
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发表时间：
1998-04-01
期刊：
影响因子：
5.3
通讯作者：
Collen, D
中科院分区：
文献类型：
--
作者：
Holvoet, P;Collen, D
丙二醛（MDA）修饰和氧化的低密度脂蛋白（LDL）已在动脉粥样硬化病变中得到证实。mda修饰LDL特异性自身免疫抗体滴度升高预测颈动脉粥样硬化和心肌梗死的进展。最近，在缺血性心脏病患者血浆中检测到mda修饰LDL水平升高，而在缺血性心脏病患者和心脏移植后并发心血管疾病患者血浆中检测到氧化LDL水平升高。虽然抗氧化修饰LDL的自身免疫抗体水平升高和氧化LDL抗原水平升高似乎与动脉粥样硬化性心血管疾病有关，但迄今为止还没有直接证据证明氧化LDL在动脉粥样硬化血栓形成中的因果作用。然而，与抗氧化剂（如维生素E）、雌激素补充和高密度脂蛋白（HDL）水平增加相关的心血管疾病风险降低，可能至少部分是由于抑制LDL的氧化或氧化LDL的动脉粥样硬化血栓作用的逆转。(C) 1998爱思唯尔科学爱尔兰有限公司版权所有。
Malondialdehyde (MDA)-modified and oxidized low density lipoproteins (LDL) have been demonstrated in atherosclerotic lesions. Elevated titers of autoimmune antibodies specific for MDA-modified LDL predicted the progression of carotid atherosclerosis and of myocardial infarction. Recently, elevated levels of MDA-modified LDL were detected in the plasma of patients with ischemic heart disease, whereas, elevated levels of oxidized LDL were detected in the plasma of patients with ischemic heart disease and of heart transplant patients with post-transplant cardiovascular disease. Although increased levels of autoimmune antibodies against oxidatively modified LDL and increased levels of oxidized LDL antigen appear to be associated with atherosclerotic cardiovascular disease, there is to date no direct proof of the causal role of oxidized LDL in atherothrombosis. However, the decreased risk of cardiovascular disease associated with the administration of antioxidants (e.g. vitamin E), estrogen supplementation and increased levels of high density lipoproteins (HDL) may, at least partially, be due to the inhibition of oxidation of LDL or to the reversal of the atherothrombotic effects of oxidized LDL. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.