Gene therapy in autoimmune diseases
Gene therapy in autoimmune diseases
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DOI：
10.1136/ard.57.3.125
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发表时间：
1998-03-01
影响因子：
27.4
通讯作者：
Robbins, PD
中科院分区：
文献类型：
--
作者：
Evans, CH;Whalen, JD;Robbins, PD
最后，还有一个问题是，是局部地将基因输送到疾病活动的离散区域，还是系统地输送基因及其产物变得更加普遍地分布。局部给药产生的副作用较少，适用于自身免疫性疾病，如Grave‘s病，主要影响离散的解剖位置。相比之下，全身给药似乎更适合于狼疮等播散性自身免疫性疾病的治疗。目前尚不清楚局部或全身给药，还是两者的某种组合最适用于RA，尽管RA主要是检查关节，但也有重要的关节外部件。
Finally, there is the issue of whether to deliver genes locally to discrete areas of disease activity or systemically, where the genes and their products become more generally distributed. Local delivery produces less side eVects and is suitable for autoimmune diseases, such as Grave’s disease, which primarily aVects a discrete anatomical location. Systemic delivery, in contrast, seems better suited to the treatment of disseminated autoimmune diseases like lupus. It is unclear whether local or systemic delivery, or some combination of the two, would be most applicable to RA, which, although primarily aVecting joints, has important extraarticular components.