Acoustic Radiation Force Impulse Imaging for Evaluation of Renal Parenchyma Elasticity in Diabetic Nephropathy
Acoustic Radiation Force Impulse Imaging for Evaluation of Renal Parenchyma Elasticity in Diabetic Nephropathy
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DOI：
10.2214/ajr.14.12493
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发表时间：
2015-02-01
影响因子：
5
通讯作者：
Hattapoglu, Salih
中科院分区：
文献类型：
--
作者：
Goya, Cemil;Kilinc, Faruk;Hattapoglu, Salih
目标。本研究的目的是利用声辐射力脉冲成像评估糖尿病肾病肾实质弹性的变化。研究对象和方法。该研究包括281名健康志愿者和114名糖尿病肾病患者。在健康志愿者中，通过基于年龄、体重指数和性别的声辐射力脉冲成像测量剪切波速度来定量评估肾脏弹性。比较糖尿病肾病不同阶段与健康对照组肾脏弹性的变化。在健康志愿者中，横波速度值与年龄和性别之间存在统计学上显著的相关性。1期、2期、3期、4期和5期糖尿病肾病患者肾脏的剪切波速度值分别为2.87、3.14、2.95、2.68和2.55 m/s，而健康对照组为2.35 m/s。声辐射力脉冲成像能够区分肾脏中不同的糖尿病肾病阶段（除了第5期）。预测糖尿病肾病的阈值为2.43 m/s（敏感性84.1%，特异性67.3%，阳性预测值93.1%，阴性预测值50.8%，准确率72.1%，阳性似然比2.5，阴性似然比0.23）。声辐射力脉冲成像可用于评价糖尿病肾病继发性结构和功能改变引起的肾弹性改变。
OBJECTIVE. The goal of this study is to evaluate the changes in the elasticity of the renal parenchyma in diabetic nephropathy using acoustic radiation force impulse imaging.SUBJECTS AND METHODS. The study included 281 healthy volunteers and 114 patients with diabetic nephropathy. In healthy volunteers, the kidney elasticity was assessed quantitatively by measuring the shear-wave velocity using acoustic radiation force impulse imaging based on age, body mass index, and sex. The changes in the renal elasticity were compared between the different stages of diabetic nephropathy and the healthy control group.RESULTS. In healthy volunteers, there was a statistically significant correlation between the shear-wave velocity values and age and sex. The shear-wave velocity values for the kidneys were 2.87, 3.14, 2.95, 2.68, and 2.55 m/s in patients with stage 1, 2, 3, 4, and 5 diabetic nephropathy, respectively, compared with 2.35 m/s for healthy control subjects. Acoustic radiation force impulse imaging was able to distinguish between the different diabetic nephropathy stages (except for stage 5) in the kidneys. The threshold value for predicting diabetic nephropathy was 2.43 m/s (sensitivity, 84.1%; specificity, 67.3%; positive predictive value, 93.1%; negative predictive value 50.8%; accuracy, 72.1%; positive likelihood ratio, 2.5; and negative likelihood ratio, 0.23).CONCLUSION. Acoustic radiation force impulse imaging could be used for the evaluation of the renal elasticity changes that are due to secondary structural and functional changes in diabetic nephropathy.