Postadsorptive transitions in fibrinogen: influence of polymer properties.
Postadsorptive transitions in fibrinogen: influence of polymer properties.
复制标题
纤维蛋白原的吸附后转变：聚合物特性的影响。
DOI：
10.1002/jbm.820241002
复制
发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Horbett,TA
中科院分区：
文献类型：
--
作者：
Rapoza,RJ;Horbett,TA
Changes in the fibrinogen molecule after its adsorption to biomaterials may be important in determining blood compatibility. Previously, postadsorptive transitions were detected by measuring the elutability of adsorbed proteins with surfactant solutions. The elutability decreased with increased residence time, suggesting that protein—surface interactions increased with residence time. In this study, we have examined the effects of polymer structure and composition, chain mobility, and hydrophobicity on the postadsorptive transitions of fibrinogen. Glassy, rigid polymers showed high fibrinogen adsorption, regardless of whether the polymer was hydrophilic or hydrophobic. However, the binding strength (as measured by elutability) was much lower on hydrophilic polymers and oxygen‐containing hydrophobic polymers. Short‐term transitions, requiring 2 h or less after adsorption, were observed only on hydrophobic polymers that contained no oxygen. More gradual transitions were observed on hydrophobic polymers containing oxygen, but only after a lag time of 1–4 h.
