Evaluation of C-reactive protein and total serum cholesterol in adult patients with bipolar disorder
Evaluation of C-reactive protein and total serum cholesterol in adult patients with bipolar disorder
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DOI：
10.1177/039463200802100208
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发表时间：
2008-04-01
影响因子：
3.5
通讯作者：
Ferro, F. M.
中科院分区：
文献类型：
--
作者：
De Berardis, D.;Conti, C. M.;Ferro, F. M.
本研究的目的是评估CRP和总胆固醇（TC）在I型双相情感障碍（BD-I）患者中的作用。此外，我们的目标是阐明可能的CRP和TC的差异，在不同阶段的BD-I：急性躁狂症，心境正常和双相抑郁症。回顾性分析90例BD-Ⅰ型患者（30例为急性躁狂期，30例为正常、完全缓解期，30例为抑郁期）的病历资料，评价血清CRP和TC水平。同时收集了30例健康对照者的实验室检查资料。采用Young躁狂量表（YMRS）、Bech-Rafaelsen躁狂量表（BRMRS）和汉密尔顿抑郁量表（HAM-D）进行评定。急性躁狂期和抑郁期亚组的CRP水平高于健康对照组。急性躁狂期CRP与BRMRS和YMRS评分呈正相关，抑郁期CRP与HAM-D评分呈正相关。与对照组相比，所有临床组的TC水平均较低。TC水平与BRMRS、YMRS、HAM-D呈负相关。总之，本研究的结果支持了BP-I患者CRP和TC可能发生改变的观点。
The aim of the present study is to evaluate the role of CRP and Total Cholesterol (TC) in patients suffering from type I Bipolar Disorder (BD-I). Moreover, the goal is to elucidate possible CRP and TC differences in different phases of BD-I: acute mania, euthymia and bipolar depression. Medical records of 90 BD-I patients (30 patients with acute mania, 30 in euthymic state, full remission, and 30 in depressive phase) were reviewed to evaluate serum CRP and TC levels. Laboratory data of 30 healthy controls were also obtained. The scores of Young Mania Rating Scale (YMRS), Bech-Rafaelsen Manic Rating Scale (BRMRS) and Hamilton Rating Scale for Depression (HAM-D) were evaluated. CRP levels were higher in acute mania and depressive phase subgroups when compared to healthy controls. CRP was positively associated with BRMRS and YMRS scores in acute mania and with HAM-D in depressive phase subgroups. TC levels were lower in all clinical groups compared to controls. TC levels were negatively correlated to BRMRS, YMRS and HAM-D. In conclusion, the results of the present study support the notion that CRP and TC may be altered in patients with BP-I.