Oral Magnesium supplementation improves insulin sensitivity in non-diabetic subjects with insulin resistance.: A double-blind placebo-controlled randomized trial
Oral Magnesium supplementation improves insulin sensitivity in non-diabetic subjects with insulin resistance.: A double-blind placebo-controlled randomized trial
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DOI：
10.1016/s1262-3636(07)70116-7
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发表时间：
2004-06-01
影响因子：
7.2
通讯作者：
Rodríguez-Morán, M
中科院分区：
文献类型：
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作者：
Guerrero-Romero, F;Tamez-Perez, HE;Rodríguez-Morán, M
目的：虽然低镁血症降低了胰岛素敏感性，但补充镁对非糖尿病胰岛素抵抗患者的益处尚未确定。我们的目的是确定每天口服含氯化镁2.5g的镁是否能改善非糖尿病患者的胰岛素敏感性。材料和方法：这是一项为期3个月的随机、双盲、安慰剂对照试验。明显健康的受试者如果有胰岛素抵抗(HOMA-IR指数等于或大于3.0)和低镁血症(血清镁水平等于或低于0.74 mmol/L)就有资格参加。受试者被随机分为两组，每天服用氯化镁2.5g或服用安慰剂3个月。结果：在基线水平，两组之间没有显著的人体测量学或实验室差异。在研究结束时，补充镁的受试者显著提高了他们的血清镁水平(0.0001.61+/-0.08至0.81+/-0.08 mmol/L，p<；)，并降低了HOMA-IR指数(4.6+/-2.8至2.6+/-1.11p<；0.0001)，而对照组无显著差异(P=0.063)。结论：口服补镁改善了非糖尿病患者的胰岛素敏感性。这一发现的临床意义必须得到证实。
Objective: Although hypomagnesemia reduces insulin sensitivity, benefits of magnesium supplementation to non-diabetic insulin resistant subjects has not been established. Our purpose was to determine whether oral magnesium supplementation with magnesium chloride (MgCl2) 2.5 g daily modify insulin sensitivity in non-diabetic subjects.Material and Methods: This study was a 3 months randomized double-blind placebo-controlled trial. Apparently healthy subjects were eligible to participate if they had insulin resistance (HOMA-IR index equal or greater than 3.0) and hypomagnesemia (Serum magnesium levels equal or lower than 0.74 mmol/l). Subjects were randomized to receive either, MgCl2 2.5 g daily or placebo by 3-months.Results: At baseline there were not significant anthropometric or laboratory differences between both groups. At ending of the study, magnesium-supplemented subjects significantly increased their serum magnesium levels (0.61 +/- 0.08 to 0.81 +/- 0.08 mmol/l, p < 0.0001) and reduced HOMA-IR index (4.6 +/- 2.8 to 2.6 +/- 1.11 p < 0.0001), whereas control subjects did not (0.62 +/- 0.08 to 0.61 +/- 0.08 mmol/l, p = 0.063 and 5.2 +/- 1.9 to 5.3 +/- 2.9, p = 0.087).Conclusions: Oral magnesium supplementation improves insulin sensitivity in hypomagnesemic non-diabetic subjects. Clinical implications of this finding have to be established.