Glucose metabolism in cancer cells
Glucose metabolism in cancer cells
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DOI：
10.1097/mco.0b013e32833a5577
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发表时间：
2010-07-01
影响因子：
3.1
通讯作者：
Widmann, Christian
中科院分区：
文献类型：
--
作者：
Annibaldi, Alessandro;Widmann, Christian
综述目的
癌细胞改变其代谢以支持其在体内的快速增殖和扩散。特别是，肿瘤细胞通常将葡萄糖用于有氧糖酵解，而非在氧化磷酸化途径中利用葡萄糖。在本综述中，我们讨论了一些被认为与癌细胞获得糖酵解表型有关的机制，以及向糖酵解的转变如何体现出一种选择性生长优势。
近期发现
葡萄糖剥夺可激活癌基因，这些癌基因可上调参与有氧糖酵解的蛋白质。反过来，与糖酵解增加有关的蛋白质可使肿瘤细胞更抗凋亡。有氧糖酵解导致肿瘤环境酸化，有利于更具侵袭性和转移性表型的发展。改变肿瘤周围的pH值可能是一种阻碍肿瘤发展的方法，正如最近一项研究表明，碳酸氢盐可提高肿瘤的pH值，防止自发转移。
总结
转化细胞获得糖酵解表型赋予这些细胞一种选择性生长优势。因此，干扰有氧糖酵解是一种选择性靶向癌细胞的潜在有效策略。
Purpose of reviewCancer cells alter their metabolism in order to support their rapid proliferation and expansion across the body. In particular, tumor cells, rather than fueling glucose in the oxidative phosphorylation pathway, generally use glucose for aerobic glycolysis. In this review, we discuss some of the mechanisms thought to be responsible for the acquisition of a glycolytic phenotype in cancer cells and how the switch towards glycolysis represents a selective growth advantage.Recent findingsGlucose deprivation can activate oncogenes and these can upregulate proteins involved in aerobic glycolysis. In turn, proteins implicated in increased glycolysis can render tumor cells more resistant to apoptosis. Aerobic glycolysis induces acidification of the tumor environment, favoring the development of a more aggressive and invasive phenotype. Altering the pH around tumors might represent a way to hamper tumor development as suggested by a recent work demonstrating that bicarbonate, which increases the pH of tumors, prevented spontaneous metastatization.SummaryThe acquisition of a glycolytic phenotype by transformed cells confers a selective growth advantage to these cells. Interfering with aerobic glycolysis, therefore, represents a potentially effective strategy to selectively target cancer cells.