Cl- and nonselective cation channels in the basolateral membrane of strial marginal cells in the cochlea.
Cl- and nonselective cation channels in the basolateral membrane of strial marginal cells in the cochlea.
复制标题
耳蜗纹状体边缘细胞基底外侧膜中的 Cl- 和非选择性阳离子通道。
DOI：
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复制
发表时间：
1994
期刊：
影响因子：
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通讯作者：
A. Irimajiri
中科院分区：
文献类型：
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作者：
S. Takeuchi;A. Irimajiri
边缘细胞离子转运和耳蜗内电位（EP）产生的机制仍然存在争议。通过膜片钳技术研究了沙鼠分离的纹状体边缘细胞的基底外侧膜的传导通路。经常识别出两种类型的离子通道：80 pS Cl- 和 25 pS Ca(2+) 激活的非选择性阳离子。在讨论纹状体边缘细胞在产生 EP 中的作用时，必须考虑到这两个通道作为基底外侧膜中 Na+、K+ 和 Cl- 的传导途径的丰度。
The mechanisms underlying the marginal cells' ion transport and endocochlear potential (EP) generation are still controversial. Conductive pathways in the basolateral membrane of isolated strial marginal cells of the gerbil have been investigated by the patch-clamp technique. Two types of ion channel, 80 pS Cl- and 25 pS Ca(2+)-activated nonselective cation, were identified frequently. The abundance of these two channels as the conductive pathways for Na+, K+, and Cl- in the basolateral membrane must be taken into account when addressing the role of strial marginal cells in generating EP.