+49A/G polymorphism of cytotoxic T-lymphocyte antigen 4 gene in type 1 autoimmune hepatitis and primary biliary cirrhosis: A meta-analysis
+49A/G polymorphism of cytotoxic T-lymphocyte antigen 4 gene in type 1 autoimmune hepatitis and primary biliary cirrhosis: A meta-analysis
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DOI：
10.1111/j.1872-034x.2010.00757.x
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发表时间：
2011-02-01
影响因子：
4.2
通讯作者：
Yamamoto, Kazuhide
中科院分区：
文献类型：
--
作者：
Miyake, Yasuhiro;Ikeda, Fusao;Yamamoto, Kazuhide
目的：细胞毒性T淋巴细胞抗原4（CTLA-4）基因+49A/G多态性与1型自身免疫性肝炎（AIH）和原发性胆汁性肝硬化（PBC）易感性的关系近年来有报道，但这些关系尚未完全阐明。本研究采用Meta分析方法探讨CTLA-4基因+49 A/G多态性与1型AIH和PBC易感性的关系。结果：G/G纯合性与1型AIH易感性无关，但G等位基因与1型AIH易感性的比值比（OR）为1.26 [95%可信区间（CI）为1.06-1.51]。另一方面，A/A纯合性对1型AIH的OR为0.66（95%CI 0.50-0.86）。PBC中G等位基因的OR值为1.20（95% CI 1.06-1.34）。G/G纯合性与PBC的易感性显著相关（OR 1.29，95% CI 1.01-1.66）。结论：CTLA-4基因+49 A/G多态性可能与1型AIH和PBC的易感性有关。特别是G/G基因型可能与PBC的易感性有关，而A/A基因型可能对1型AIH和PBC具有保护作用。
Aim:Recently, the associations of +49A/G polymorphisms of cytotoxic T-lymphocyte antigen 4 (CTLA-4) gene with the susceptibility to type 1 autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) have been reported; however these associations are yet to be fully elucidated. This study aimed to identify the associations of CTLA-4 gene +49A/G polymorphisms with the susceptibility to type 1 AIH and PBC by using a meta-analysis.Methods:PubMed was searched by using the following keywords: "autoimmune hepatitis AND (polymorphism OR polymorphisms)" or "primary biliary cirrhosis AND (polymorphism OR polymorphisms)". Meta-analyses of five studies including 526 patients with type 1 AIH and 631 controls and seven studies including 1500 patients with PBC and 2345 controls were performed.Results:For type 1 AIH, the odds ratio (OR) of G allele was 1.26 [95% confidence interval (CI) 1.06-1.51] although G/G homozygosity was not associated with the susceptibility to type 1 AIH. On the other hand, the OR of A/A homozygosity for type 1 AIH was 0.66 (95% CI 0.50-0.86). For PBC, the OR of G allele was 1.20 (95% CI 1.06-1.34). Furthermore, G/G homozygosity was significantly associated with the susceptibility to PBC (OR 1.29, 95% CI 1.01-1.66). The OR of A/A homozygosity for PBC was 0.81 (95% CI 0.70-0.94).Conclusions:This study suggests that CTLA-4 gene +49A/G polymorphisms may be associated with the susceptibility to type 1 AIH and PBC. Especially, while G/G genotype may be associated with the susceptibility to PBC, A/A genotype may be protective against type 1 AIH and PBC.