Multifunctional Gold Nanoshells on Silica Nanorattles: A Platform for the Combination of Photothermal Therapy and Chemotherapy with Low Systemic Toxicity
Multifunctional Gold Nanoshells on Silica Nanorattles: A Platform for the Combination of Photothermal Therapy and Chemotherapy with Low Systemic Toxicity
复制标题
DOI：
10.1002/anie.201002820
复制
发表时间：
2011-01-01
影响因子：
16.6
通讯作者：
Tang, Fangqiong
中科院分区：
文献类型：
--
作者：
Liu, Huiyu;Chen, Dong;Tang, Fangqiong
等离子体纳米材料，特别是那些可以将近红外（NIR）光转化为热量的纳米材料，已被开发为用于局部热疗癌症治疗的光热剂。 Halas 的研究小组首次在固体二氧化硅球上应用金纳米壳涂层用于肿瘤消融，[1] 制备了一系列近红外光吸收等离子体纳米材料，可以杀死致瘤细胞而不损伤正常细胞，例如金纳米棒 (GNR)、[2] 金纳米笼、[3] AuxAg1Àx 树突、[4] 金 聚苯乙烯球上的纳米壳，[5]组装金纳米颗粒，[6]和许多多功能纳米复合材料。[7]基于这些等离子体纳米材料的有吸引力的光热特性来优化癌症治疗并实现增强的抗肿瘤功效，热疗和化疗药物的组合是一种令人鼓舞的方法，它可以产生更大的协同效应 比单独使用两种治疗方法。据报道，GNR 会产生热量以增加化疗药物的毒性。[8]但通过简单地混合 GNR 和化疗药物，热化疗的协同效应很难在体内实现，因为将化疗药物与珍贵的 GNR 诱导的热源共同递送至靶组织仍然具有挑战性。重要的是，尽管已经设计了基于近红外吸收纳米材料的不同多功能系统[7]，但这些系统的许多参数仅在细胞系统中进行了体外评估，而没有对这些系统进行体内研究。
Plasmonic nanomaterials, especially those that can convert near-infrared (NIR) light into heat, have been developed as photothermal agents for localized hyperthermia cancer therapy. After Halas s research group first applied a coating of gold nanoshells on solid silica spheres for tumor ablation,[1] a series of NIR-light-absorbing plasmonic nanomaterials have been fabricated to kill tumorigenic cells without damaging normal cells, such as gold nanorods (GNRs),[2] gold nanocages,[3] AuxAg1Àx dendrites,[4] gold nanoshells on polystyrene spheres,[5] assembled gold nanoparticles,[6] and many multifunctional nanocomposites.[7]Based on the attractive photothermal property of these plasmonic nanomaterials to optimize cancer therapy and achieve enhanced antitumor efficacy, the combination of hyperthermia and chemotherapeutic agents is an encouraging approach, which can result in synergistic effects that are greater than the two treatments alone. GNRs were reported as producing heat to augment the toxicity of chemotherapeutic agents.[8] But by simply mixing GNRs and chemotherapeutic agents, the synergistic effects of thermo-chemotherapy are difficult to realize in vivo because co-delivery of chemotherapeutic agents together with precious GNR-induced hyperthermia sources to the target tissues is still challenging. Importantly, even though different multifunctional systems based on NIR-absorbing nanomaterials have been designed,[7] many parameters of these systems were only assessed in vitro in cellular systems, while no in vivo study of