Serine/Threonine Protein Kinases from Bacteria, Archaea and Eukarya Share a Common Evolutionary Origin Deeply Rooted in the Tree of Life
Serine/Threonine Protein Kinases from Bacteria, Archaea and Eukarya Share a Common Evolutionary Origin Deeply Rooted in the Tree of Life
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DOI：
10.1016/j.jmb.2017.11.004
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发表时间：
2018-01-05
影响因子：
5.6
通讯作者：
Mijakovic, Ivan
中科院分区：
文献类型：
--
作者：
Stancik, Ivan Andreas;Sestak, Martin Sebastijan;Mijakovic, Ivan
Hanks 等人定义并描述了真核生物中存在的丝氨酸/苏氨酸/酪氨酸蛋白激酶的主要家族。 1988 年（《科学》，241, 42-52）。最初人们认为这些激酶不存在于细菌中，但广泛的基因组测序揭示了它们存在于许多细菌中。由于历史原因，术语“真核型激酶”在文献中传播以描述该蛋白质家族的细菌成员。在这里，我们认为这个术语作为用词不当而应该被放弃，并且我们提供了几条证据来支持这一主张。我们全面的系统地层学分析表明，真核生物、细菌和古细菌中存在的汉克斯型激酶在导致最后普遍共同祖先（LUCA）的谱系中都具有共同的进化起源。我们没有发现任何证据表明编码汉克斯型激酶的基因从真核生物水平转移到细菌。此外，我们的系统结构比较表明，细菌汉克斯型激酶与真核对应物非常相似，而它们的结构似乎与细菌来源的其他激酶家族不同。这表明细菌激酶可能进化出与真核汉克斯型激酶相似的激酶结构域的趋同进化场景不太可能。总的来说，我们的结果强烈支持所有 Hanks 型激酶的单系起源，因此我们建议应采用该术语作为该蛋白质家族的通用名称。 (C) 2017 年作者。由爱思唯尔有限公司出版
The main family of serine/threonine/tyrosine protein kinases present in eukarya was defined and described by Hanks et al. in 1988 (Science, 241, 42-52). It was initially believed that these kinases do not exist in bacteria, but extensive genome sequencing revealed their existence in many bacteria. For historical reasons, the term "eukaryotic-type kinases" propagated in the literature to describe bacterial members of this protein family. Here, we argue that this term should be abandoned as a misnomer, and we provide several lines of evidence to support this claim. Our comprehensive phylostratigraphic analysis suggests that Hanks-type kinases present in eukarya, bacteria and archaea all share a common evolutionary origin in the lineage leading to the last universal common ancestor (LUCA). We found no evidence to suggest substantial horizontal transfer of genes encoding Hanks-type kinases from eukarya to bacteria. Moreover, our systematic structural comparison suggests that bacterial Hanks-type kinases resemble their eukaryal counterparts very closely, while their structures appear to be dissimilar from other kinase families of bacterial origin. This indicates that a convergent evolution scenario, by which bacterial kinases could have evolved a kinase domain similar to that of eukaryal Hanks-type kinases, is not very likely. Overall, our results strongly support a monophyletic origin of all Hanks-type kinases, and we therefore propose that this term should be adopted as a universal name for this protein family. (C) 2017 The Author(s). Published by Elsevier Ltd.