Efficacy of rifabutin-loaded microspheres for treatment of Mycobacterium avium-infected macrophages and mice.
Efficacy of rifabutin-loaded microspheres for treatment of Mycobacterium avium-infected macrophages and mice.
复制标题
负载利福布丁的微球治疗鸟分枝杆菌感染的巨噬细胞和小鼠的功效。
DOI：
10.1080/10717540600739815
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发表时间：
2007
期刊：
影响因子：
6
通讯作者：
Staas,JayK
中科院分区：
文献类型：
--
作者：
Barrow,EstherLW;Barrow,WilliamW;Quenelle,DebraC;Westbrook,Louise;Winchester,GaryA;Staas,JayK
Two poly(DL-lactide-co-glycolide) microsphere formulations (A, 10% wt/wt, and B, 23% wt/wt, 1–10 microns) were evaluated for intracellular delivery of rifabutin using the J774 murine and Mono Mac 6 (MM6) human monocytic cell lines. Within 7 days, formulation A released 100% in both cell lines and B released 53 and 67% in the J774 and MM6, respectively. Intracellular release of rifabutin with both formulations caused significant reduction of intracellularly replicatingMycobacterium avium(MAC). In MAC-infected beige mice, formulation B (50 mg, intraperitoneal days 0 and 7) completely eliminated infection by 21 days (p< 0.001), similar to a rifabutin daily oral regimen.
