Feasibility of Doppler variance imaging for red blood cell aggregation characterization.
Feasibility of Doppler variance imaging for red blood cell aggregation characterization.
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DOI：
10.1117/1.3275464
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发表时间：
2009-11
影响因子：
3.5
通讯作者：
Xiangqun Xu;Yeh-Chan Ahn;Zhongping Chen
中科院分区：
文献类型：
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作者：
Xiangqun Xu;Yeh-Chan Ahn;Zhongping Chen
红细胞（RBC）聚集水平异常是一种与许多病理相关的临床状况。我们的目的是探讨谱域相位分辨光学多普勒断层扫描结合多普勒方差成像来表征流动血液中红细胞聚集的可行性。测量猪血在4.7 mm时流过直径为300微米的玻璃管的多普勒频谱的方差/标准差（SD）。对于红细胞比容为20,40和60%的非聚集红细胞，平均中心线SD值分别为34.2+/-1.2,47.8+/-1.0和47.2+/-0.5。葡聚糖500诱导后，聚集血SD值分别显著降低至29.9+/-0.7、37.9+/-3.0和40.1+/-0.6 （P<0.01）。结果表明，利用SD值进行多普勒方差成像能够区分正常血和聚集血。
An abnormal level of red blood cell (RBC) aggregation is a clinical condition associated with many pathologies. Our purpose is to investigate the feasibility of spectral domain phase-resolved optical Doppler tomography incorporated with Doppler variance imaging to characterize RBC aggregation in flowing blood. Variance/standard deviation (SD) of the Doppler frequency spectrum of porcine blood flowing through a glass tube (diameter 300 microm) at 4.7 mms is measured. For nonaggregating RBCs with hematocrits of 20, 40, and 60%, the mean centerline SD values were 34.2+/-1.2, 47.8+/-1.0, and 47.2+/-0.5, respectively. After dextran 500 induction, the SD value decreased significantly to 29.9+/-0.7, 37.9+/-3.0, and 40.1+/-0.6 (P<0.01) in the aggregated blood, respectively. The results demonstrate that Doppler variance imaging using the SD value is capable of differentiating normal and aggregated blood.