Multidrug-resistant Mycobacterium tuberculosis, Bangui, Central African Republic.
Multidrug-resistant Mycobacterium tuberculosis, Bangui, Central African Republic.
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DOI：
10.3201/eid1209.060361
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发表时间：
2006-09
影响因子：
11.8
通讯作者：
Gicquel B
中科院分区：
文献类型：
--
作者：
Nouvel LX;Kassa-Kelembho E;Dos Vultos T;Zandanga G;Rauzier J;Lafoz C;Martin C;Blazquez J;Talarmin A;Gicquel B
我们调查了中非共和国班吉的耐多药结核分枝杆菌菌株。我们发现39.6%的mutT1基因具有相同的spoligotype和同义的单核苷酸多态性。然而，菌株具有不同的rpoB突变，导致利福平耐药。班吉的耐多药菌株可能优先出现于单一耐多药易发家族。
We investigated multidrug-resistant (MDR) Mycobacterium tuberculosis strains in Bangui, Central African Republic. We found 39.6% with the same spoligotype and synonymous single nucleotide polymorphism in the mutT1 gene. However, strains had different rpoB mutations responsible for rifampin resistance. MDR strains in Bangui may emerge preferentially from a single, MDR-prone family.