Two alternative transcripts coding for alcohol dehydrogenase accumulate with different developmental specificities in different species of picture-winged Drosophila.
Two alternative transcripts coding for alcohol dehydrogenase accumulate with different developmental specificities in different species of picture-winged Drosophila.
复制标题
编码乙醇脱氢酶的两种替代转录物在不同种类的图翅果蝇中以不同的发育特异性积累。
DOI：
10.1093/genetics/114.2.435
复制
发表时间：
1986
期刊：
影响因子：
3.3
通讯作者：
Dickinson,WJ
中科院分区：
文献类型：
--
作者：
Rowan,RG;Dickinson,WJ
单拷贝乙醇脱氢酶（Adh）基因的两个交替转录本在所有12种夏威夷彩翼果蝇中积累，并具有发育特异性。相对于范例物种D. affinidisjuncta的Adh转录本在幼虫和成虫组织中均有积累。另一种Adh转录本通常只在成虫中积累，在三龄幼虫中积累。前须贝幼虫也是在种间杂种中，D.表型为加性遗传。这些观察记录了一种新型遗传变异的存在。此外，这些变体表明调节果蝇ADH表达的生物系统的特定特性，它们应该有助于进一步的实验研究。
Two alternate transcripts of the single copyAlcohol dehydrogenase(Adh) gene accumulate with developmental specificity in all of 12 species of Hawaiianpicture-wingedDrosophila which have been examined. Relative to the paradigm speciesD. affinidisjuncta, theAdhtranscript normally restricted to larvae is found to accumulate in both larval and adult tissues inD. formella. The otherAdhtranscript, which normally accumulates only in adults, accumulates in third-instarD. prostopalpislarvae as well. In species hybrids, theD. formellaphenotype shows additive inheritance. These observations document the existence of a novel type of genetic variability. Furthermore, such variants suggest specific properties for the biological systems that regulate ADH expression in Drosophila, and they should facilitate further experimental investigations.