INTRACORTICAL GENERATORS OF THE FLASH VEP IN MONKEYS
INTRACORTICAL GENERATORS OF THE FLASH VEP IN MONKEYS
复制标题
DOI：
10.1016/0168-5597(85)90007-3
复制
发表时间：
1985-01-01
期刊：
影响因子：
--
通讯作者：
VAUGHAN, HG
中科院分区：
文献类型：
--
作者：
KRAUT, MA;AREZZO, JC;VAUGHAN, HG
用闪光视觉诱发电位(VEP)在非麻醉猕猴的大脑皮质表面和密集的皮质内部位记录，并记录相关的多单位活动(MUA)。用电流源密度(CSD)分析VEP的深度分布，以描绘细胞外源和汇表现的跨膜电流的层状模式。初始表面记录成分(P15和P18)是在丘脑皮质辐射的皮质下产生的。与随后的两个表面负成分N24和N40相关的电流源和汇的分布表明，它们分别产生于IVa层和IVCb层，这两个层都是丘脑的微小细胞。在N40上观察到类似于人类VEP的振荡电位；MUA结合与这些小波一致的源和汇的分析提供了证据，表明它们来自丘脑和皮质的活动。在20-60ms范围内的MUA在整个IVA板层呈相性增加，在IVA板层内幅度最大。这种放电的增加与在小细胞丘脑皮质亚胺IVCb和IVa内观察到的汇是同时发生的。随后的一个成分p65，与MUA下降到低于与IVCb板层电流源共存的自发水平一致，可能来自于IVCb内产生的抑制活动。下一个VEP成分是95ms的表面负电位，与III层的电流源和电流汇一致，也与星状细胞对颗粒上元素的输入一致。N95之后的VEP成分与MUA或CSD活性无关，可能是纹外皮质产生的。提出了类人猿视觉诱发电位的概念。
Flash visual evoked potentials (VEP) in unanesthetized monkeys were recorded from the cortical surface and from closely spaced intracortical sites together with associated multiple unit activity (MUA). The VEP depth profiles were subjected to current source density (CSD) analysis to delineate the laminar pattern of transmembrane current flows manifested by extracellular sources and sinks. The initial surface recorded components (P15 and P18) were generated subcortically within the thalamocortical radiations. The distribution of current sources and sinks associated with 2 subsequent surface negative components, N24 and N40, demonstrates their generation within laminae IVA and IVCb, respectively, both parvocellular thalamorecipient layers. Oscillatory potentials resembling those seen in human VEP are observed riding on N40; analysis of MUA in conjunction with sources and sinks coincident with these wavelets provides evidence that they derive from both thalamocortical and cortical activity. MUA in the 20-60 ms range shows phasic increases throughout lamina IV, which are maximum in amplitude within lamina IVA. This increased firing is concurrent with the sinks observed within the parvocellular thalamorecipient sublaminae IVCb and IVA. A subsequent component, P65, coincident with a decrease in MUA to below the spontaneous level co-located with a lamina IVCb current source, probably arises from intracortically generated inhibitory activity within IVCb. The next VEP component, a surface negative potential at 95 ms, is coincident with current sources and sinks in lamina III, and is consistent with stellate cell input to supragranular elements. VEP components after N95 are not associated with either MUA or CSD activity and are probably generated in extrastriate cortex. Human counterparts of the simian VEP are proposed.