Inflammation: a key regulator of hematopoietic stem cell fate in health and disease
Inflammation: a key regulator of hematopoietic stem cell fate in health and disease
复制标题
DOI：
10.1182/blood-2017-06-780882
复制
发表时间：
2017-10-12
期刊：
影响因子：
20.3
通讯作者：
Pietras, Eric M.
中科院分区：
文献类型：
--
作者：
Pietras, Eric M.
造血干细胞（HSC）负责终身生成血细胞。与此同时，他们必须对感染或受伤等紧急需求做出快速反应。人们对炎症如何调节 HSC 的命运以及它如何影响 HSC 和整个血液系统的长期功能产生了浓厚的兴趣。在此，我们详细介绍了在发育、衰老和血液恶性肿瘤背景下炎症和造血干细胞生物学交叉点的最新进展和未解答的问题。
Hematopoietic stem cells (HSCs) are responsible for lifelong production of blood cells. At the same time, they must respond rapidly to acute needs such as infection or injury. Significant interest has emerged in how inflammation regulates HSC fate and how it affects the long-term functionality of HSCs and the blood system as a whole. Herewedetail recent advancesand unanswered questions at the intersection between inflammation and HSC biology in the contexts of development, aging, and hematological malignancy.