Prognostic significance of neutrophil-to-lymphocyte ratio in non-small cell lung cancer: a meta-analysis.
Prognostic significance of neutrophil-to-lymphocyte ratio in non-small cell lung cancer: a meta-analysis.
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非小细胞肺癌中嗜中性粒细胞与淋巴细胞比的预后意义：一项荟萃分析。
DOI：
10.1038/srep12493
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发表时间：
2015-07-24
影响因子：
4.6
通讯作者：
Zhang XJ
中科院分区：
文献类型：
--
作者：
Gu XB;Tian T;Tian XJ;Zhang XJ
关于中性粒细胞与淋巴细胞比率 (NLR) 在非小细胞肺癌 (NSCLC) 中的预后意义的已发表数据存在争议。我们进行了荟萃分析，以更准确地评估其预后价值。该分析基于 14 项研究（涉及 3,656 名患者）的数据进行，以估计 NLR 与 NSCLC 总生存期 (OS) 和无进展生存期 (PFS) 之间的相关性。计算具有 95% 置信区间 (CI) 的风险比 (HR) 以评估效果。我们还进行了亚组分析和元回归分析。结果表明，治疗前 NLR 升高预示 NSCLC 患者的 OS（HR：1.70，95% CI：1.39-2.09）和 PFS（HR：1.63，95% CI：1.27-2.09）较差。亚组分析表明，5 的截止值显示出一致的预后价值。纳入研究的 OS 和 PFS 不存在显着异质性或发表偏倚。这项荟萃分析表明，治疗前 NLR 升高可能是 NSCLC 患者预后不良的预测因素。
Published data on the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) in non-small cell lung cancer (NSCLC) are controversial. We performed a meta-analysis to more accurately assess its prognostic value. The analysis was performed based on the data from 14 studies with 3,656 patients to estimate the correlation between NLR and overall survival (OS) and progression-free survival (PFS) in NSCLC. Hazard ratio (HR) with 95% confidence interval (CI) were calculated to estimate the effect. We also conducted subgroup analysis and meta-regression analysis. The results demonstrated that elevated pretreatment NLR predicted poorer OS (HR: 1.70, 95% CI: 1.39–2.09) and PFS (HR: 1.63, 95% CI: 1.27–2.09) in patients with NSCLC. Subgroup analysis indicated that cut-off value of 5 showed consistently prognostic value. There was no significant heterogeneity or publication bias for OS and PFS for included studies. This meta-analysis revealed that elevated pretreatment NLR might be a predicative factor of poor prognosis for NSCLC patients.