The ins and outs of syntenin, a multifunctional intracellular adaptor protein
The ins and outs of syntenin, a multifunctional intracellular adaptor protein
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DOI：
10.1242/jcs.026401
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发表时间：
2008-05-01
影响因子：
4
通讯作者：
Coffer, Paul J.
中科院分区：
文献类型：
--
作者：
Beekman, Jeffrey M.;Coffer, Paul J.
细胞生物学家目前面临的最具挑战性的问题之一是如何实现信号特异性和区室化，允许细胞外刺激导致独特的和预定义的细胞内结果。要做到这一点，细胞内成分必须在空间和时间上正确定位。含有蛋白质相互作用结构域的衔接子分子通常参与组织细胞内信号转导途径的多聚体复合物的组装。一种这样的蛋白质是syntenin，一种含有PDZ结构域的分子，具有令人惊讶的多样性和多样性的相互作用伴侣。在这里，我们吸收和讨论目前的数据支持的作用，突触蛋白在调节跨膜受体贩运，肿瘤细胞转移和神经元突触功能。
One of the most challenging issues currently facing cell biologists is how signal specificity and compartmentalization is achieved, allowing extracellular stimulation to result in a unique and predefined intracellular outcome. For this to occur, intracellular components must be correctly positioned in both space and time. Adaptor molecules, which contain protein-interaction domains, are often involved in the assembly of multimeric complexes that organize intracellular signal-transduction pathways. One such protein is syntenin, a PDZ-domain-containing molecule that has a surprising variety and diversity of interaction partners. Here we assimilate and discuss current data that support a role for syntenin in regulating transmembrane-receptor trafficking, tumour-cell metastasis and neuronal-synapse function.