Flower Necklaces of Controllable Length Formed From N-(2-Hydroxypropyl) Methacrylamide-Based Amphiphilic Statistical Copolymers
Flower Necklaces of Controllable Length Formed From N-(2-Hydroxypropyl) Methacrylamide-Based Amphiphilic Statistical Copolymers
复制标题
N-(2-羟丙基)甲基丙烯酰胺基两亲统计共聚物形成的可控长度花项链
DOI：
10.1021/acs.langmuir.0c02032
复制
发表时间：
2020
期刊：
影响因子：
3.9
通讯作者：
Sakurai Kazuo
中科院分区：
文献类型：
--
作者：
Takahashi Rintaro;Doi Kiyomasa;Fujii Shota;Sakurai Kazuo
基于N-（2-羟丙基）甲基丙烯酰胺（HPMA）的具有抗癌药物的统计共聚物因其在癌症治疗中的功效而引起关注。然而，控制这种类型的聚合物的聚集体的尺寸和形态一直是具有挑战性的，并且还远未被理解。在这项研究中，小角X射线散射和非对称流场流分馏与多角度光散射被用来研究在水溶液中形成的聚集体的结构的HPMA为基础的统计共聚物的不同分子量的模型药物芘承担在不同量。分析表明，在低分子量共聚物中，芘基团的组装形成了球状物（花状胶束），而在高分子量共聚物中，花状胶束呈线性连接，形成了串珠状组装体（花项链）.每个聚合物链的芘部分的数量可能主导共聚物胶束的大小和形态。这项研究表明，如何改变聚集体结构，通过改变共聚物的分子量和组成。
N-(2-Hydroxypropyl)methacrylamide (HPMA)-based statistical copolymers bearing anticancer drugs have attracted attention for their efficacy in cancer treatments. However, controlling the size and morphology of aggregates of this type of polymer has been challenging and is far from being understood. In this study, small-angle X-ray scattering and asymmetric-flow field-flow fractionation with multiangle light scattering were used to investigate the structure of aggregates formed in aqueous solutions of HPMA-based statistical copolymers of different molecular weights with the model drug pyrene borne in different amounts. The analysis revealed that spherical objects (flower micelles) were formed by the assembly of pyrene moieties in low-molecular-weight copolymers, and the flower micelles connected linearly to form string-of-pearls assemblies (flower necklaces) in high-molecular-weight copolymers. The number of pyrene moieties per polymer chain likely dominates the size and morphology of the copolymer micelles. This study shows how to alter the aggregate structure by changing the molecular weight and composition of copolymers.