Erectile dysfunction is associated with low bioactive testosterone levels and visceral adiposity in men with type 2 diabetes
Erectile dysfunction is associated with low bioactive testosterone levels and visceral adiposity in men with type 2 diabetes
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DOI：
10.1111/j.1365-2605.2007.00744.x
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发表时间：
2007-12-01
影响因子：
--
通讯作者：
Jones, T. H.
中科院分区：
文献类型：
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作者：
Kapoor, D.;Clarke, S.;Jones, T. H.
男性睾酮水平低与2型糖尿病有关。勃起功能障碍（艾德）是2型糖尿病的常见并发症。我们的横断面研究的目的是调查艾德和总的，生物可利用的和游离睾酮水平之间的关系，在198名男性2型糖尿病患者。此外，我们还研究了2型糖尿病男性患者中参与艾德发展的各种心血管危险因素的相关性。我们发现艾德男性的生物可利用性和游离睾酮水平明显较低（分别为p = 0.006和0.027）。性激素结合球蛋白水平也降低，但总睾酮（TT）无显著性差异由国际勃起功能指数评分评估的艾德的严重程度与勃起功能指数评分显著相关。TT（r = 0.32; p < 0.001）、生物可利用睾酮（r = 0.32; p < 0.001）和计算的游离睾酮（r = 0.35; p < 0.001）水平。艾德在高血压和腰围较大的男性中更常见（p = 0.03）。吸烟者中艾德的患病率也较高（p = 0.06），但艾德与饮酒或BMI > 30之间没有显著相关性。这项研究表明，艾德与低生物利用度和游离睾酮水平，年龄，内脏肥胖和高血压的2型糖尿病男性。
Low testosterone levels in men are associated with type 2 diabetes mellitus. Erectile dysfunction (ED) is a frequent complication of type 2 diabetes. The aim of our cross-sectional study was to investigate the relationship between ED and total, bioavailable and free testosterone levels in 198 men with type 2 diabetes. In addition, we examined the associations of various cardiovascular risk factors involved in the development of ED in type 2 diabetic men. We found that bioavailable and free testosterone levels were significantly lower in men with ED (p = 0.006 and 0.027 respectively) than those without ED. Sex hormone-binding globulin levels were also reduced, but there was no significant difference in total testosterone (TT) levels between men with and without ED. The severity of ED as assessed by International Index of Erectile Function scores was significantly associated with TT (r = 0.32; p < 0.001), bioavailable testosterone (r = 0.32; p < 0.001) and calculated free testosterone (r = 0.35; p < 0.001) levels. ED was more frequently observed in men with hypertension and a higher waist circumference (p = 0.03). There was also a higher prevalence of ED among smokers (p = 0.06), but there were no significant associations between ED and alcohol consumption or with BMI > 30. This study has shown that ED is associated with low bioavailable and free testosterone levels, age, visceral adiposity and hypertension in type 2 diabetic men.