Association and linkage of anxiety-related traits with a functional polymorphism of the serotonin transporter gene regulatory region in Israeli sibling pairs
Association and linkage of anxiety-related traits with a functional polymorphism of the serotonin transporter gene regulatory region in Israeli sibling pairs
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DOI：
10.1038/sj.mp.4000660
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发表时间：
2000-03-01
影响因子：
11
通讯作者：
Benjamin, J
中科院分区：
文献类型：
--
作者：
Osher, Y;Hamer, D;Benjamin, J
据报道，血清素转运体基因（5 - HTTLPR）调控区域的一种功能性多态性与焦虑相关的人格测量指标既有关联又有连锁关系，尽管其他研究未重复这些发现。本研究在148名以色列受试者（包括74对同性兄弟姐妹）样本中，检验了该基因与两种主要的焦虑相关人格测量指标的关联和连锁关系，这两种指标分别是三维人格问卷中的伤害回避量表和NEO - PI - R中的神经质量表。我们重复了之前报道的短等位基因与三维人格问卷伤害回避量表（P = 0.03），包括羞怯分量表（P = 0.02）得分较高之间的关联，并且还发现短等位基因与NEO - PI - R神经质量表中的焦虑（P = 0.03）和抑郁（P = 0.04）分量表之间存在相同方向的关联。使用回归方法进行的同胞对连锁分析进一步支持了5 - HTTLPR在焦虑相关人格特质中的作用。
A functional polymorphism in the regulatory region of the serotonin transporter gene (5-HTTLPR) has been reported to be both associated and linked to anxiety-related personality measures, although other studies have not replicated these findings. The current study examines both association and linkage of the gene to two major anxiety-related personality measures, the harm avoidance scale on the Tridimensional Personality Questionnaire and the neuroticism scale of the NEO-PI-R, in a sample of 148 Israeli subjects comprising 74 same-sex sibling pairs. We replicated the reported association between the short allele and higher scores on the TPQ harm avoidance scale (P=0.03), including the subscale of shyness (P=0.02), and also found association in the same direction between the short allele and the NEO-PI-R neuroticism subscales of anxiety (P = 0.03) and depression (P = 0.04). Sib-pair linkage analysis, using the regression method, further supported a role of the 5-HTTLPR in anxiety-related personality traits.