Periods of cardiovascular susceptibility to hypoxia in embryonic american alligators (Alligator mississippiensis).
Periods of cardiovascular susceptibility to hypoxia in embryonic american alligators (Alligator mississippiensis).
复制标题
美洲短吻鳄胚胎时期心血管对缺氧的敏感性（密西西比短吻鳄）。
DOI：
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
D. Crossley
中科院分区：
文献类型：
--
作者：
Kevin B. Tate;T. Rhen;J. Eme;Z. Kohl;Janna L. Crossley;R. Elsey;D. Crossley
在胚胎发育过程中，环境扰动会影响生物体的发育表型，这一过程被称为发育可塑性。由此产生的表型变化可能发生在离散的，关键的发展窗口。关键窗口是发育中的胚胎最容易受到这些干扰的时期。我们以前已经证明，缺氧减少胚胎大小和增加相对心脏质量在美国短吻鳄，这项研究确定了关键窗口时，缺氧改变形态，心血管功能和心脏基因表达的短吻鳄胚胎。我们假设，在缺氧（10%O2）孵育将增加相对心脏的大小，由于心脏扩大，而不是抑制体细胞生长。我们将鳄鱼胚胎暴露于缺氧在离散的孵化期，以目标窗口，胚胎表型发生变化。缺氧影响心脏生长的20和40%之间的胚胎孵化，而体细胞生长的影响70和90%之间的孵化。动脉压被压抑的缺氧暴露在50-70%的孵化，而心脏率被压抑在胚胎暴露于缺氧在一段时间内跨越70-90%的孵化。在某些缺氧暴露的胚胎处理组中，VEGF和PdgfB的表达增加，并且在孵育结束时缺氧改变了动脉压和心率的β-肾上腺素能张力。众所周知，缺氧暴露可以改变胚胎发育，在本研究中，我们已经确定了短暂的，离散的窗口，改变形态，心血管生理学和基因表达在胚胎美洲鳄。
During embryonic development, environmental perturbations can affect organisms' developing phenotype, a process known as developmental plasticity. Resulting phenotypic changes can occur during discrete, critical windows of development. Critical windows are periods when developing embryos are most susceptible to these perturbations. We have previously documented that hypoxia reduces embryo size and increases relative heart mass in American alligator, and this study identified critical windows when hypoxia altered morphological, cardiovascular function and cardiac gene expression of alligator embryos. We hypothesized that incubation in hypoxia (10% O2) would increase relative cardiac size due to cardiac enlargement rather than suppression of somatic growth. We exposed alligator embryos to hypoxia during discrete incubation periods to target windows where the embryonic phenotype is altered. Hypoxia affected heart growth between 20 and 40% of embryonic incubation, whereas somatic growth was affected between 70 and 90% of incubation. Arterial pressure was depressed by hypoxic exposure during 50-70% of incubation, whereas heart rate was depressed in embryos exposed to hypoxia during a period spanning 70-90% of incubation. Expression of Vegf and PdgfB was increased in certain hypoxia-exposed embryo treatment groups, and hypoxia toward the end of incubation altered β-adrenergic tone for arterial pressure and heart rate. It is well known that hypoxia exposure can alter embryonic development, and in the present study, we have identified brief, discrete windows that alter the morphology, cardiovascular physiology, and gene expression in embryonic American alligator.
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DOI：
10.1152/ajpregu.00771.2007
发表时间：
2008-08-01
影响因子：
2.8
作者：
Ream, Margie;Ray, Alisa M.;Chikaraishi, Dona M.
通讯作者：
Chikaraishi, Dona M.
DOI：
10.1152/ajpheart.1987.252.6.h1228
发表时间：
1987
期刊：
The American journal of physiology
影响因子：
--
作者：
Adair,TH;Guyton,AC;Montani,JP;Lindsay,HL;Stanek,KA
通讯作者：
Stanek,KA
自发钙瞬变出现在再生肌肉中，并且是骨骼肌补充所必需的。
影响因子：
4
作者：
Tu,MichelleKim;Borodinsky,LauraNoemi
通讯作者：
Borodinsky,LauraNoemi
通过氧气供应量的短暂（72 小时）变化来调节鸡胚的生长和代谢。
DOI：
--
发表时间：
1987
期刊：
The Journal of experimental zoology. Supplement : published under auspices of the American Society of Zoologists and the Division of Comparative Physiology and Biochemistry
影响因子：
--
作者：
Stock,MK;Metcalfe,J
通讯作者：
Metcalfe,J
DOI：
10.1016/s1095-6433(99)00159-2
发表时间：
2000-01-01
影响因子：
2.3
作者：
Corona, TB;Warburton, SJ
通讯作者：
Warburton, SJ