Evidence of dysregulated peripheral oxytocin release among depressed women.
Evidence of dysregulated peripheral oxytocin release among depressed women.
复制标题
DOI：
10.1097/psy.0b013e318188ade4
复制
发表时间：
2008-11
影响因子：
3.3
通讯作者：
Amico JA
中科院分区：
文献类型：
--
作者：
Cyranowski JM;Hofkens TL;Frank E;Seltman H;Cai HM;Amico JA
催产素是一种下丘脑神经肽，在哺乳动物雌性生殖功能中起关键作用。动物研究表明，中枢催产素促进适应性社会依恋，调节压力和焦虑反应。重度抑郁症在青春期后的女性中普遍存在，并且与社会依恋的扰动、下丘脑-垂体-肾上腺应激轴的失调以及焦虑水平的升高有关。因此，抑郁的女性可能有催产素失调的风险。本研究旨在比较抑郁和非抑郁女性外周催产素释放的模式。目前患有抑郁症（N = 17）和从未患有抑郁症（N = 17）的女性参与了一项实验室方案，该方案旨在刺激、测量和比较外周催产素释放以响应两项任务：以关系为中心的引导意象任务和言语压力任务。在两个1小时的疗程中，包括20分钟的基线期、10分钟的任务期和30分钟的恢复期，采集间歇性血样。10分钟的实验室任务没有引起外周催产素的可识别的急性变化。然而，与非抑郁的对照组相比，抑郁的女性在两个1小时的会议过程中，脉冲式催产素释放的变异性更大，在1小时的联系集中的图像会议期间，催产素浓度更高。在想象过程中获得的催产素浓度也与抑郁、焦虑和人际功能障碍的症状有关。抑郁的女性比对照组更容易表现出外周催产素释放的失调模式。进一步的研究是必要的，以阐明外周催产素释放在抑郁症和非抑郁症妇女的临床意义。
Oxytocin is a hypothalamic neuropeptide that plays a key role in mammalian female reproductive function. Animal research indicates that central oxytocin facilitates adaptive social attachments and modulates stress and anxiety responses. Major depression is prevalent among postpubertal females, and is associated with perturbations in social attachments, dysregulation of the hypothalamic-pituitary-adrenal stress axis, and elevated levels of anxiety. Thus, depressed women may be at risk to display oxytocin dysregulation. The current study was developed to compare patterns of peripheral oxytocin release exhibited by depressed and nondepressed women. Currently depressed (N = 17) and never-depressed (N = 17) women participated in a laboratory protocol designed to stimulate, measure, and compare peripheral oxytocin release in response to two tasks: an affiliation-focused Guided Imagery task and a Speech Stress task. Intermittent blood samples were drawn over the course of two, 1-hour sessions including 20-minute baseline, 10-minute task, and 30-minute recovery periods. The 10-minute laboratory tasks did not induce identifiable, acute changes in peripheral oxytocin. However, as compared with nondepressed controls, depressed women displayed greater variability in pulsatile oxytocin release over the course of both 1-hour sessions, and greater oxytocin concentrations during the 1-hour affiliation-focused imagery session. Oxytocin concentrations obtained during the imagery session were also associated with greater symptoms of depression, anxiety, and interpersonal dysfunction. Depressed women are more likely than controls to display a dysregulated pattern of peripheral oxytocin release. Further research is warranted to elucidate the clinical significance of peripheral oxytocin release in both depressed and nondepressed women.