Estrogen receptor gene polymorphism and craniofacial morphology in female TMJ osteoarthritis patients
Estrogen receptor gene polymorphism and craniofacial morphology in female TMJ osteoarthritis patients
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DOI：
10.1016/j.ijom.2005.06.009
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发表时间：
2006-02-01
影响因子：
2.4
通讯作者：
Kim, ST
中科院分区：
文献类型：
--
作者：
Lee, DG;Kim, TW;Kim, ST
为探讨雌激素受体α（ER α）基因多态性对女性颞下颌关节（TMJ）骨关节炎（OA）患者颅面骨骼的影响，选取76名无血缘关系的韩国女性患者作为研究对象，根据颞下颌关节紊乱病诊断标准（RDC-TMD）诊断为OA。采用直接单倍型分析法对Pvull和XbaI两个位点的RFLP进行分析。12头影测量进行评估的空间位置和尺寸的下颌骨。使用Mann-Whitney's U检验来确定根据Px单倍型携带者状态分组的受试者之间头影测量的潜在差异。此外，通过X-2检验进一步分析Px单倍型与症状性OA患者颅面形态的关系，发现携带Px单倍型的女性症状性TMJOA患者的面轴角（P < 0.05）和下颌体长（P <0.05）均显著小于非携带者。Px单倍型的存在和短下颌体长度之间的关联也被确定。这项研究表明，ER α基因多态性有助于改变女性症状性颞下颌关节OA患者的下颌骨尺寸。进一步研究颅面生长和适应相关的遗传标记的作用有望拓宽我们对颅面形态决定因素的理解。
The aim of this study was to investigate the possible influence of estrogen receptor alpha (ER alpha) polymorphism oil the craniofacial skeleton in female patients suffering from symptomatic osteoarthritis (OA) of the temporomandibular joint (TMJ).The sample comprised 76 genetically unrelated Korean women diagnosed with OA by research diagnostic criteria for temporomandibular disorders (RDC-TMD). Direct haplotyping procedure was used to analyze the Pvull and Xbal RFLPs. Twelve cephalometric measurements were taken to evaluate the spatial position and dimensions of the mandible. Mann-Whitney's U-test was used to identify the potential differences in the cephalometric measurements between the subjects grouped according to their carrier status for Px haplotype. In addition, all association study was carried out using X-2-test to further examine the relationship between Px haplotype and the craniofacial morphology of the symptomatic OA patients.Female symptomatic TMJ OA patients carrying Px haplotype showed significantly smaller facial axis angle (P < 0.05) and mandibular body length (P < 0.05) than the non-carriers. The association between the presence of Px haplotype and short mandibular body length was also ascertained. This study suggests that ERa polymorphism contributes to the altered mandibular dimensions in female symptomatic TMJ OA patients. Further studies oil the role of the genetic markers relevant to the craniofacial growth and adaptation are expected to broaden our understanding of determinants of the craniofacial morphology.