An Overview of Helicobacter pylori Survival Tactics in the Hostile Human Stomach Environment.
An Overview of Helicobacter pylori Survival Tactics in the Hostile Human Stomach Environment.
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DOI：
10.3390/microorganisms9122502
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发表时间：
2021-12-03
期刊：
影响因子：
4.5
通讯作者：
Wong WF
中科院分区：
文献类型：
--
作者：
Cheok YY;Lee CYQ;Cheong HC;Vadivelu J;Looi CY;Abdullah S;Wong WF
幽门螺杆菌是胃炎、消化性溃疡和胃癌的病原体。这种革兰氏阴性细菌具有各种独特的毒力因子，是少数能够避开胃部恶劣环境的微生物之一。独特的螺旋结构、鞭毛和外膜蛋白加速幽门螺杆菌在粘性胃粘膜层内的运动，同时促进其附着在上皮细胞上。此外，幽门螺旋杆菌分泌的脲酶缓解了胃内的酸性pH值，从而为细菌的生存和复制创造了一个生态位。细菌蛋白CagA在胃上皮内层站稳脚跟后，通过IV型分泌系统（T4SS）注入宿主细胞，与VacA一起破坏胃上皮细胞。幽门螺旋杆菌不仅在胃中建立定植，而且还操纵宿主免疫系统以允许长期存在。长期幽门螺旋杆菌感染会导致胃癌前的慢性炎症。本文综述了幽门螺杆菌生存策略、细菌-宿主相互作用及其在治疗干预和疫苗开发中的重要性。
Helicobacter pylori is well established as a causative agent for gastritis, peptic ulcer, and gastric cancer. Armed with various inimitable virulence factors, this Gram-negative bacterium is one of few microorganisms that is capable of circumventing the harsh environment of the stomach. The unique spiral structure, flagella, and outer membrane proteins accelerate H. pylori movement within the viscous gastric mucosal layers while facilitating its attachment to the epithelial cells. Furthermore, secretion of urease from H. pylori eases the acidic pH within the stomach, thus creating a niche for bacteria survival and replication. Upon gaining a foothold in the gastric epithelial lining, bacterial protein CagA is injected into host cells through a type IV secretion system (T4SS), which together with VacA, damage the gastric epithelial cells. H. pylori does not only establishes colonization in the stomach, but also manipulates the host immune system to permit long-term persistence. Prolonged H. pylori infection causes chronic inflammation that precedes gastric cancer. The current review provides a brief outlook on H. pylori survival tactics, bacterial-host interaction and their importance in therapeutic intervention as well as vaccine development.
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影响因子：
7.3
作者：
Cheok YY;Tan GMY;Fernandez KC;Chan YT;Lee CYQ;Cheong HC;Looi CY;Vadivelu J;Abdullah S;Wong WF
通讯作者：
Wong WF
影响因子：
3.1
作者：
EATON, KA;BROOKS, CL;KRAKOWKA, S
通讯作者：
KRAKOWKA, S
DOI：
10.1073/pnas.0502040102
发表时间：
2005-06-28
影响因子：
11.1
作者：
Andersen-Nissen, E;Smith, KD;Aderem, A
通讯作者：
Aderem, A
影响因子：
6.7
作者：
Debowski AW;Walton SM;Chua EG;Tay AC;Liao T;Lamichhane B;Himbeck R;Stubbs KA;Marshall BJ;Fulurija A;Benghezal M
通讯作者：
Benghezal M
幽门螺杆菌和胃癌：参与疾病进展的适应性细胞机制。
影响因子：
5.2
作者：
Díaz P;Valenzuela Valderrama M;Bravo J;Quest AFG
通讯作者：
Quest AFG