Some metabolism studies - With special reference to mental disorders
Some metabolism studies - With special reference to mental disorders
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DOI：
10.1176/ajp.60.4.699
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发表时间：
1904-04-01
影响因子：
--
通讯作者：
Hill, LA
中科院分区：
文献类型：
--
作者：
Folin, O;Shaffer, P;Hill, LA
表8给出了从七个正常人中获得的尿成分的平均值，每个人都保持在液体实验室饮食一周。在表格的底部给出了所有的最终平均值，即35个24小时尿量的平均值。在此，我们再次注意到，这些正常尿液所显示的各种比率和百分比具有相当的一致性。从对患者进行的类似喂养实验中获得的超出这些对照人员设定的限度的任何显著偏差都被认为表明存在一种或另一种形式的异常代谢。当然，这一结论的正确性取决于7个对照组代表正常变异的准确性。在以下页面中，将提供通过对患者进行的类似研究获得的分析材料。最初的意图是，在获得与每一精神病组相对应的相当大量的病例之前，不公布这些调查结果，然后根据这样的分类来安排结果。但随着调查范围的扩大和分析的更加完整，早期的案件。分析工作中所涉及的不那么充分，不能再与后来更全面研究的案例联系起来使用。由于这个原因，也由于这样一个事实，即迄今为止的调查未能显示出任何与不同精神病相对应的特征性代谢特点。
Table No. 8 gives the averages of the urinary constituents obtained from seven normal persons, each of whom was kept on the liquid laboratory diet for one week. At the bottom of the table is given the final average of all, ie, the average of thirtyfive 24-hour quantities of urine. The comparative uniformity in the various ratios and percentages shown by these normal urines should again be noted here. Any striking deviations outside the limits set by these control persons obtained from similar feeding experiments with patients are held to indicate the presence of one or another form of abnormal metabolism. The validity of such a conclusion depends of course upon the accuracy with which the seven control persons represent the normal variations.EXPERIMENTS WITH PATIENTS. On the following pages will be presented analytical material obtained by similar studies on patients. The original intention was not to publish these investigations until a fairly large number of cases corresponding to each of the psychiatrical groups had been obtained, and then to arrange the results according to such a classification. But as the investigations have broadened in scope and the analyses have become more complete, the earlier cases. less fully covered by the analytical work, can no longer be used to advantage in connection with the later, more completely studied cases. For this reason and also on account of the fact that the investigations have so far failed to show any characteristic metabolism peculiarities corresponding to the different psychiatrical