Pulmonary Function at Hospital Discharge in Preterm Infants Randomized to a Single Rescue Course of Antenatal Steroids.
Pulmonary Function at Hospital Discharge in Preterm Infants Randomized to a Single Rescue Course of Antenatal Steroids.
复制标题
早产婴儿的医院出院时肺功能随机分为产前类固醇的单个救援过程。
DOI：
10.1016/j.jpeds.2016.10.022
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发表时间：
2017-02
期刊：
影响因子：
--
通讯作者：
McEvoy CT
中科院分区：
文献类型：
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作者：
Jordan BK;Schilling D;McEvoy CT
比较母亲随机接受产前类固醇与安慰剂单次补救治疗的婴儿在出生时和出院时测量的肺功能。一项随机双盲试验的出院随访。在最初的试验中，AS初始病程后> 14天和妊娠< 34周的孕妇被随机分配到救援AS或安慰剂组。44名母亲（56名婴儿）接受了补救AS，41名母亲（57名婴儿）接受了安慰剂。在出生和出院时测量被动呼吸顺应性（Crs）和阻力（Rrs）以及功能残气量（FRC），以评价肺力学随时间的变化。统计分析基于意向治疗。我们以前报道过，与安慰剂组相比，急救AS组的婴儿在出生后72小时内的Crs增加（1.21 vs 1.01 mL/cm H2O/kg，安慰剂组; p<0.05）。在这里，我们表明，治疗组的Crs效益持续到出院。安慰剂组婴儿的Crs改善，出院时，急救AS组和安慰剂组之间的Crs无差异（1.18 vs 1.22 mL/cm H2O/kg）。抢救AS显着增加Crs出生后72小时内测量，这种增加持续到出院。安慰剂组早产儿的初始Crs较AS急救组降低，但出院时Crs与AS急救组相当。
To compare the pulmonary function, measured at birth and at hospital discharge, of infants whose mothers had been randomized to a single rescue course of antenatal steroids versus placebo. Follow-up at hospital discharge of a randomized, double-blinded trial. In the original trial, pregnant women > 14 days after their initial course of AS and < 34 weeks’ gestation were randomized to rescue AS or placebo. 44 mothers (56 infants) received rescue AS and 41 mothers (57 infants) received placebo. Passive respiratory compliance (Crs) and resistance (Rrs), and functional residual capacity (FRC), were measured at birth and discharge to evaluate changes in pulmonary mechanics over time. Statistical analyses were based on intention-to-treat. We previously reported that infants in the rescue AS compared with the placebo group demonstrated an increase in Crs measured within 72 hours of birth (1.21 vs 1.01 mL/cm H2O/kg for placebo; p<0.05). Here we show that the Crs benefit in the treated group was sustained until discharge. Infants in the placebo group demonstrated improvement in Crs such that by discharge, there was no difference in Crs between the rescue AS and placebo group (1.18 vs 1.22 mL/cm H2O/kg). Rescue AS significantly increases Crs measured within 72 hours of birth and this increase is sustained until hospital discharge. Preterm infants in the placebo group demonstrate a decreased initial Crs compared with the rescue AS group, but achieve a comparable Crs with the rescue AS group by discharge.