The methylerythritol phosphate pathway contributes to carotenoid but not phytol biosynthesis in Euglena gracilis.

The methylerythritol phosphate pathway contributes to carotenoid but not phytol biosynthesis in Euglena gracilis.
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甲基赤藓糖醇磷酸途径有助于眼虫中类胡萝卜素的生物合成,但不促进植醇的生物合成。

DOI:
10.1021/np049892x
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发表时间:
2004
期刊:
Journal of natural products.
影响因子:
--
通讯作者:
Proteau,PhilipJ
Proteau,PhilipJ
中科院分区:
--
文献类型:
--
作者:
Kim,Dojung;Filtz,MichaelR;Proteau,PhilipJ

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以[1- 13 C]-d-葡萄糖和[5,5 - 2 H2]-1-脱氧-d-木酮糖为底物,研究了纤细裸藻(Euglena gracilis)生物合成二甲藻黄素和β-胡萝卜素的情况。与以往在E. gracilis中,结果证明了甲基异丙基磷酸(MEP)途径,沿着甲羟戊酸途径,在类胡萝卜素生物合成中的作用。有趣的是,MEP途径不参与植醇的生物合成,这是以前在其他含叶绿体的生物中没有观察到的结果。
The biosynthesis of diadinoxanthin and β-carotene inEuglena graciliswas examined using [1-13C]-d-glucose and [5,5-2H2]-1-deoxy-d-xylulose. In contrast to previous studies on isoprenoid biosynthesis inE. gracilis, the results demonstrate a role for the methylerythritol phosphate (MEP) pathway, along with the mevalonate pathway, in carotenoid biosynthesis. Interestingly, the MEP pathway is not involved in the biosynthesis of phytol, a result not previously observed for other chloroplast-containing organisms.