PURIFICATION AND SEQUENCE OF A PRESYNAPTIC PEPTIDE TOXIN FROM CONUS-GEOGRAPHUS VENOM
PURIFICATION AND SEQUENCE OF A PRESYNAPTIC PEPTIDE TOXIN FROM CONUS-GEOGRAPHUS VENOM
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DOI：
10.1021/bi00317a001
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发表时间：
1984-01-01
期刊：
影响因子：
2.9
通讯作者：
GRAY, WR
中科院分区：
文献类型：
--
作者：
OLIVERA, BM;MCINTOSH, JM;GRAY, WR
Baldomcro M. Olivera、* J. Michael McIntosh、* Lourdes J. Cruz、F. A. Luque § 和 William R. Gray 摘要：一种来自食鱼海洋软体动物 Conus geographus 毒液的新型毒素 - 芋螺毒素 (-CgTX) 已被纯化并进行生化表征。最近，这种芋螺毒素已被证明可以抑制电压激活的 Ca2+ 进入，从而为探索脊椎动物突触前末梢提供了潜在的强大探针 [Kerr, L. M., & Yoshikami, D.(1984) Nature (London) 308, 282-284]。
Baldomcro M. Olivera,* J. Michael McIntosh,* Lourdes J. Cruz, F. A. Luque, § and William R. Gray abstract: A novel toxin,-conotoxín (-CgTX), from the venom of the fish-eating marine mollusc Conus geographus has been purified and biochemically characterized. Recently, this-conotoxin has been shown to inhibit the voltage-activated entry of Ca2+, thus providing a potentially powerful probe for exploring the vertebrate presynaptic terminal [Kerr, L. M., & Yoshikami, D.(1984) Nature (London) 308, 282-284].