The kinetics of chemically induced nonequilibrium swelling of articular cartilage and corneal stroma.
The kinetics of chemically induced nonequilibrium swelling of articular cartilage and corneal stroma.
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DOI：
10.1115/1.3138647
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发表时间：
1987-02
期刊：
影响因子：
--
通讯作者：
S. Eisenberg;A. Grodzinsky
中科院分区：
文献类型：
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作者：
S. Eisenberg;A. Grodzinsky
建立了带电水合组织的机电模型，用于预测由浴盐浓度变化引起的肿胀和等长压应力变化的动力学。该模型着重于离子传输作为速率限制步骤，在化学调制细胞外基质的带电大分子之间的电相互作用。对这种局部相互作用力变化的膨胀反应是由组织样品中化学扩散和流体重新分配的相对速率决定的。我们通过比较实验观察到的牛关节软骨和角膜基质中盐诱导的应力松弛反应与使用相关研究中报告的组织的浓度依赖材料特性的本构关系模型预测的反应来测试该模型。我们的实验测量和模型预测之间在质量上的良好一致性支持了模型的物理基础，并证明了模型区分所检测的两种软结缔组织的能力。
An electromechanical model for charged, hydrated tissues is developed to predict the kinetics of changes in swelling and isometric compressive stress induced by changes in bath salt concentration. The model focuses on ionic transport as the rate limiting step in chemically modulating electrical interactions between the charged macromolecules of the extracellular matrix. The swelling response to such changes in local interaction forces is determined by the relative rates of chemical diffusion and fluid redistribution in the tissue sample. We have tested the model by comparing the experimentally observed salt-induced stress relaxation response in bovine articular cartilage and corneal stroma to the response predicted by the model using constitutive relations for the concentration dependent material properties of the tissues reported in a related study. The qualitatively good agreement between our experimental measurements and the predictions of the model supports the physical basis of the model and demonstrates the model's ability to discriminate between the two soft connective tissues that were examined.