ANTICRYPTOCOCCAL ACTIVITY OF NK CELL-ENRICHED PERIPHERAL-BLOOD LYMPHOCYTES FROM HUMAN IMMUNODEFICIENCY VIRUS-INFECTED SUBJECTS - RESPONSES TO INTERLEUKIN-2, INTERFERON-GAMMA, AND INTERLEUKIN-12
ANTICRYPTOCOCCAL ACTIVITY OF NK CELL-ENRICHED PERIPHERAL-BLOOD LYMPHOCYTES FROM HUMAN IMMUNODEFICIENCY VIRUS-INFECTED SUBJECTS - RESPONSES TO INTERLEUKIN-2, INTERFERON-GAMMA, AND INTERLEUKIN-12
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DOI：
10.1093/infdis/172.4.1023
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发表时间：
1995-10-01
影响因子：
6.4
通讯作者：
WASHBURN, RG
中科院分区：
文献类型：
--
作者：
HORN, CA;WASHBURN, RG
从早期无症状或晚期人类免疫缺陷病毒（HIV）感染的患者中获得的高度纯化的NK细胞的抗隐球菌活性被证明明显受损;通过在体外添加外源性白细胞介素-12（IL-12），活性可重现地恢复到正常水平。对于这些高度纯化的NK细胞，HIV感染患者对IL-2和干扰素-γ（IFN-γ）的反应是可变的，8例患者中只有2例对IL-2或IFN-γ表现出显著反应。相比之下，11。2和IFN-γ一致增强的混合淋巴细胞群的抗隐球菌活性，细胞更接近的网络可能是在体内操作。
Anticryptococcal activity of highly purified NK cells from patients with either early asymptomatic or late-stage human immunodeficiency virus (HIV) infection proved to be markedly impaired; activity was reproducibly restored to normal levels by in vitro addition of exogenous interleukin-12 (IL-12). For these highly purified NK cells, responses to IL-2 and interferon-gamma (IFN-gamma) among HIV-infected patients were variable, with only 2 of 8 exhibiting significant responses to IL-2 or IFN-gamma. In contrast, 11.-2 and IFN-gamma consistently enhanced anticryptococcal activity of mixed lymphocyte populations, cells that more closely approximate the network likely to be operational in vivo.