Prefrontal-Hippocampal Interactions in Memory and Emotion.
Prefrontal-Hippocampal Interactions in Memory and Emotion.
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DOI：
10.3389/fnsys.2015.00170
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发表时间：
2015
影响因子：
3
通讯作者：
Maren S
中科院分区：
文献类型：
--
作者：
Jin J;Maren S
海马结构（HPC）和内侧前额叶皮层（mPFC）在记忆编码和提取中具有公认的作用。然而，HPC和mPFC在实现这些功能方面的相互作用机制尚未完全了解。大量的研究支持这样的观点，即从HPC和下托到mPFC的直接通路在记忆过程的认知和情绪调节中起着至关重要的作用。最近，有证据表明，从HPC到mPFC通过中线丘脑核reuniens（RE）的间接途径可能在空间和情绪记忆加工中发挥作用。在这里，我们将考虑HPC和mPFC之间的双向相互作用是如何参与动物和人类的工作记忆，情景记忆和情绪记忆。我们还将考虑双向HPC-mPFC通路的功能障碍如何导致精神疾病。
The hippocampal formation (HPC) and medial prefrontal cortex (mPFC) have well-established roles in memory encoding and retrieval. However, the mechanisms underlying interactions between the HPC and mPFC in achieving these functions is not fully understood. Considerable research supports the idea that a direct pathway from the HPC and subiculum to the mPFC is critically involved in cognitive and emotional regulation of mnemonic processes. More recently, evidence has emerged that an indirect pathway from the HPC to the mPFC via midline thalamic nucleus reuniens (RE) may plays a role in spatial and emotional memory processing. Here we will consider how bidirectional interactions between the HPC and mPFC are involved in working memory, episodic memory and emotional memory in animals and humans. We will also consider how dysfunction in bidirectional HPC-mPFC pathways contributes to psychiatric disorders.