Satellite glial cells represent a population of developmentally arrested Schwann cells
Satellite glial cells represent a population of developmentally arrested Schwann cells
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DOI：
10.1002/glia.23320
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发表时间：
2018-07-01
期刊：
影响因子：
6.2
通讯作者：
Lambert, Stephen
中科院分区：
文献类型：
--
作者：
George, Dale;Ahrens, Paige;Lambert, Stephen
卫星神经胶质细胞（Satellite glial cells，SGCs）是周围神经系统中的神经胶质细胞，在神经元细胞体周围形成鞘。SGCs的这种独特排列使其能够对神经元微环境施加高度调节的控制。关于SGCs的起源知之甚少。在这项研究中，我们研究了SGCs的发展。我们发现，大鼠SGCs出生后发展，这些细胞表达了一些与雪旺细胞前体相关的标志物，特别是钙粘蛋白-19（CDH 19），即使在成年DRG中。我们开发了一种纯化SGCs的方法，并表明它们在转录和形态上与成年大鼠雪旺细胞（SC）非常相似。最后，我们证明了纯化的SGCs能够髓鞘化胚胎轴突时，与这些轴突共培养。基于这些观察，我们假设SGCs代表SC谱系中的细胞群体，其进一步分化似乎通过与DRG神经元索马接触而被阻止。
Satellite glial cells (SGCs) are glial cells in the peripheral nervous system that form sheaths around the neuronal cell body. This unique arrangement of SGCs allows it to exert a highly regulated control over the neuronal microenvironment. Not much is known about the origin of SGCs. In this study, we examine the development of SGCs. We show that rat SGCs develop postnatally and these cells express a number of markers associated with Schwann cell precursors, in particular cadherin-19 (CDH19) even in adult DRGs. We developed a method for the purification of SGCs and showed that they are transcriptionally and morphologically very similar to adult rat Schwann cells (SCs). Finally, we demonstrate that purified SGCs are capable of myelinating embryonic axons when cocultured with those axons. Based on these observations we hypothesize that SGCs represent a population of cells in the SC lineage, whose further differentiation appears to be arrested through contact with DRG neuronal soma.